Human Aryl Hydrocarbon Receptor Polymorphisms That Result in Loss of CYP1A1 Induction

The aryl hydrocarbon receptor (AHR) binds xenobiotic chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and regulates transcription of the P4501 subfamily that metabolizes many carcinogens. In humans, the most frequent polymorphism is R554L. We report here an additional two polymorphisms i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-11, Vol.288 (4), p.990-996
Hauptverfasser:	Wong, Judy M.Y., Okey, Allan B., Harper, Patricia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8-tetrachlorodibenzo-p-dioxin AH receptor AHR gene Alleles Cell Line Codon - genetics Continental Population Groups - genetics CYP1A1 induction Cytochrome P-450 CYP1A1 - genetics DNA - genetics DNA - metabolism DNA Mutational Analysis Electrophoretic Mobility Shift Assay Enzyme Induction - genetics Ethnic Groups - genetics ethnic variability Gene Frequency - genetics Genetic Linkage - genetics Haplotypes - genetics Humans Mutation - genetics Polychlorinated Dibenzodioxins - pharmacology Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length polymorphisms Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptional Activation - drug effects Transfection
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