Mammalian S-phase checkpoint integrity is dependent on transformation status and purine deoxyribonucleosides

In eukaryotic cells arrested in S-phase, checkpoint controls normally restrain mitosis until after replication. We have identified an array of previously unsuspected factors that modulate this restraint, using transformed hamster cells in which cycle controls are known to be altered in S-phase arres...

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Veröffentlicht in:	Journal of cell science 2000-03, Vol.113 ( Pt 6) (6), p.1089-1096
Hauptverfasser:	Downes, C S, Bachrati, C Z, Devlin, S J, Tommasino, M, Cutts, T J, Watson, J V, Raskó, I, Johnson, R T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cdc2 protein Cell Cycle Cell Line, Transformed Cell Transformation, Viral Cricetinae cyclin B deoxyribonucleosides Mice Purines Ribonucleotide Reductases - physiology S Phase - physiology
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