Antiviral prophylaxis with twice daily topical cidofovir protects against challenge in the adenovirus type 5/New Zealand rabbit ocular model

Adenoviral ocular infections are the most common external ocular infections world wide and there is no approved treatment. Topical cidofovir has been shown to be effective in vitro, in animal models and in case studies for the treatment of adenoviral ocular infections. Prophylaxis to prevent transmi...

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Veröffentlicht in:	Antiviral research 2001-12, Vol.52 (3), p.275-280
Hauptverfasser:	Romanowski, Eric G, Yates, Kathleen A, Gordon, Y.Jerold
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Infections - drug therapy Adenoviridae Infections - prevention & control Adenoviridae Infections - virology Adenovirus Adenoviruses, Human - drug effects Adenoviruses, Human - pathogenicity Adenoviruses, Human - physiology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Biological and medical sciences Cidofovir Conjunctivitis, Viral - drug therapy Conjunctivitis, Viral - virology Cytosine - adverse effects Cytosine - analogs & derivatives Cytosine - pharmacology Cytosine - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug Epidemic keratoconjunctivitis Eye - drug effects Eye - virology Female Human adenovirus 5 Medical sciences Organophosphonates Organophosphorus Compounds - adverse effects Organophosphorus Compounds - pharmacology Organophosphorus Compounds - therapeutic use Pharmacology. Drug treatments Rabbits Virus Cultivation Virus Replication
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