AT-rich Islands in Genomic DNA as a Novel Target for AT-specific DNA-reactive Antitumor Drugs

Interstrand cross-links at T(A/T) 4 A sites in cellular DNA are associated with hypercytotoxicity of an anticancer drug, bizelesin. Here we evaluated whether these lethal effects reflect targeting critical genomic regions. An in silico analysis of human sequences showed that T(A/T) 4 A motifs are on...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (44), p.40555-40566
Hauptverfasser:	Woynarowski, J M, Trevino, A V, Rodriguez, K A, Hardies, S C, Benham, C J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - metabolism Antineoplastic Agents - pharmacology Base Sequence bizelesin DNA - chemistry DNA - drug effects DNA - genetics Duocarmycins Indoles - metabolism Thymine - metabolism Urea - analogs & derivatives Urea - metabolism
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