Morphological transformation of Syrian hamster embryo cells at pH 6.7 by bemitradine, a nongenotoxic carcinogen

Bemitradine is a compound that was intended for use as a diuretic antihypertensive drug. In the preclinical safety assays, it was found to be nongenotoxic in five in vitro assays (Ames, mouse lymphoma, CHO/HGPRT, CHO chromosome aberration, and UDS) and in one in vivo assay (mouse bone marrow micronu...

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Veröffentlicht in:	In vitro & molecular toxicology 2001, Vol.14 (2), p.121-127
Hauptverfasser:	OSHIRO, Y, BALWIERZ, P. S, MORRIS, D. L, ALDEN, C. L, BUNCH, R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetyl-aminofluorene 20-Methylcholanthrene Animals antihypertensives Bemitradine benzo(a)pyrene Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Tests - methods Cell Transformation, Neoplastic - drug effects Chemical agents Cricetinae Drug toxicity and drugs side effects treatment Embryo, Mammalian Hydrogen-Ion Concentration Medical sciences Mesocricetus methapyrilene Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments phenobarbital Pyrimidines - administration & dosage transformation Triazoles - administration & dosage Tumors
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