Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells

Effective therapeutic strategies for in vivo siRNA delivery to knockdown genes in cells outside the liver are needed to harness RNA interference for treating cancer. EpCAM is a tumor-associated antigen highly expressed on common epithelial cancers and their tumor-initiating cells (TIC, also known as...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-10, Vol.14 (10), p.2279-2291
Hauptverfasser:	Gilboa-Geffen, Adi, Hamar, Peter, Le, Minh T N, Wheeler, Lee Adam, Trifonova, Radiana, Petrocca, Fabio, Wittrup, Anders, Lieberman, Judy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Aptamers, Nucleotide - administration & dosage Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Base Sequence Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis - metabolism Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Epithelial Cell Adhesion Molecule Female Gene Expression Gene Knockdown Techniques Humans Mice, Nude Neoplasm Transplantation Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Neoplastic Stem Cells - physiology Polo-Like Kinase 1 Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Tumor Burden
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