FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy

Lafora disease (LD) is an autosomal recessive disorder characterized by epileptic seizures, neurodegeneration and accumulation of polyglucosan bodies (Lafora bodies), arising due to defects in either the laforin protein phosphatase or the malin ubiquitin ligase. Among the multiple cellular pathways...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-05, Vol.474 (2), p.321-327
Hauptverfasser:	Jain, Navodita, Mishra, Rohit, Ganesh, Subramaniam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Disease Models, Animal Down-Regulation Dual-Specificity Phosphatases - metabolism Epilepsy Forkhead Box Protein O3 - metabolism Lafora Disease - metabolism Lafora Disease - pathology Mice Mice, Knockout Neurodegeneration Post-translational modification Transcriptional regulation
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