Hypercortisolism Manifesting as Severe Weight Loss, Hypokalemia, and Hyperglycemia in the Emergency Department
Abstract Background The concurrence of ectopic adrenocorticotropic hormone (ACTH) syndrome (ectopic Cushing syndrome) and cancer is uncommon in the emergency department (ED) setting, but a constellation of nonspecific signs and symptoms can suggest the presence of Cushing syndrome. Case Report A 65-...
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| Veröffentlicht in: | The Journal of emergency medicine 2016-04, Vol.50 (4), p.e187-e190 |
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| container_title | The Journal of emergency medicine |
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| creator | Miller, Adam H., MD, MSMM, MSCS Yeung, Sai-Ching J., MD, PhD |
| description | Abstract Background The concurrence of ectopic adrenocorticotropic hormone (ACTH) syndrome (ectopic Cushing syndrome) and cancer is uncommon in the emergency department (ED) setting, but a constellation of nonspecific signs and symptoms can suggest the presence of Cushing syndrome. Case Report A 65-year-old woman with diabetes visited the ED complaining of severe weight loss, generalized weakness, and hypokalemia. She was treated for hypokalemia and thrush. She was found to have a lung mass with a large pleural effusion. Upon discovery of the suspected malignancy, the patient was referred to the ED of a comprehensive cancer center, where she was diagnosed with ectopic Cushing syndrome and admitted to the hospital for further evaluation and treatment. Why Should the Emergency Physician Be Aware of This? The emergency physician should be able to recognize Cushing syndrome in cancer patients so that the paraneoplastic syndrome can be managed to avoid complications during cancer treatment. |
| doi_str_mv | 10.1016/j.jemermed.2015.06.084 |
| format | Article |
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Case Report A 65-year-old woman with diabetes visited the ED complaining of severe weight loss, generalized weakness, and hypokalemia. She was treated for hypokalemia and thrush. She was found to have a lung mass with a large pleural effusion. Upon discovery of the suspected malignancy, the patient was referred to the ED of a comprehensive cancer center, where she was diagnosed with ectopic Cushing syndrome and admitted to the hospital for further evaluation and treatment. Why Should the Emergency Physician Be Aware of This? The emergency physician should be able to recognize Cushing syndrome in cancer patients so that the paraneoplastic syndrome can be managed to avoid complications during cancer treatment.</description><identifier>ISSN: 0736-4679</identifier><identifier>EISSN: 2352-5029</identifier><identifier>DOI: 10.1016/j.jemermed.2015.06.084</identifier><identifier>PMID: 26896288</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Cushing syndrome ; Cushing Syndrome - diagnosis ; Diagnosis, Differential ; Diagnostic Imaging ; ectopic Cushing syndrome ; Emergency ; Emergency Service, Hospital ; Female ; Humans ; hypercortisolism ; hyperglycemia ; Hyperglycemia - diagnosis ; hypokalemia ; Hypokalemia - diagnosis ; lung cancer ; malignancy ; Weight Loss</subject><ispartof>The Journal of emergency medicine, 2016-04, Vol.50 (4), p.e187-e190</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. 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Case Report A 65-year-old woman with diabetes visited the ED complaining of severe weight loss, generalized weakness, and hypokalemia. She was treated for hypokalemia and thrush. She was found to have a lung mass with a large pleural effusion. Upon discovery of the suspected malignancy, the patient was referred to the ED of a comprehensive cancer center, where she was diagnosed with ectopic Cushing syndrome and admitted to the hospital for further evaluation and treatment. Why Should the Emergency Physician Be Aware of This? The emergency physician should be able to recognize Cushing syndrome in cancer patients so that the paraneoplastic syndrome can be managed to avoid complications during cancer treatment.</description><subject>Aged</subject><subject>Cushing syndrome</subject><subject>Cushing Syndrome - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Imaging</subject><subject>ectopic Cushing syndrome</subject><subject>Emergency</subject><subject>Emergency Service, Hospital</subject><subject>Female</subject><subject>Humans</subject><subject>hypercortisolism</subject><subject>hyperglycemia</subject><subject>Hyperglycemia - diagnosis</subject><subject>hypokalemia</subject><subject>Hypokalemia - diagnosis</subject><subject>lung cancer</subject><subject>malignancy</subject><subject>Weight Loss</subject><issn>0736-4679</issn><issn>2352-5029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAUtBCILoW_UPnIoQn-dnJBoLZQpEUcStWj5XVetk4TZ7GzlfLvcdjuhUvry5PsmXl-Mw-hM0pKSqj61JUdDBAHaEpGqCyJKkklXqEV45IVkrD6NVoRzVUhlK5P0LuUOkKoJhV9i06YqmrFqmqFwvW8g-jGOPk09j4N-KcNvoU0-bDFNuEbeIQI-A789n7C6zGlc5w544PtYfD2HNvQ4H8i2352yxX2AU_3gK_y_7YQ3IwvYWfjNECY3qM3re0TfHiqp-j229Xvi-ti_ev7j4uv68IJqaZCbhohpZaKN61sa-44E6J2lIqGUaaEZhy02kjOlG211VWjGgEOWidoy23NT9HHg-4ujn_2eRoz-OSg722AcZ8MrSitSaXoC6BaK8VqLWSGqgPUxexDhNbsoh9snA0lZonFdOYYi1liMUSZHEsmnj312G-WtyPtmEMGfDkAIJvy6CGa5Hz2DhofwU2mGf3zPT7_J-F6H7yz_QPMkLpxH0O23FCTmCHmZlmOZTeoIvnUnP8Foo23NQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Miller, Adam H., MD, MSMM, MSCS</creator><creator>Yeung, Sai-Ching J., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20160401</creationdate><title>Hypercortisolism Manifesting as Severe Weight Loss, Hypokalemia, and Hyperglycemia in the Emergency Department</title><author>Miller, Adam H., MD, MSMM, MSCS ; Yeung, Sai-Ching J., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-5bd4557563df5f93c32449c114d21264723e76b5326af7a78d6d4ecefc41f3a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Cushing syndrome</topic><topic>Cushing Syndrome - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Imaging</topic><topic>ectopic Cushing syndrome</topic><topic>Emergency</topic><topic>Emergency Service, Hospital</topic><topic>Female</topic><topic>Humans</topic><topic>hypercortisolism</topic><topic>hyperglycemia</topic><topic>Hyperglycemia - diagnosis</topic><topic>hypokalemia</topic><topic>Hypokalemia - diagnosis</topic><topic>lung cancer</topic><topic>malignancy</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Adam H., MD, MSMM, MSCS</creatorcontrib><creatorcontrib>Yeung, Sai-Ching J., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>The Journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Adam H., MD, MSMM, MSCS</au><au>Yeung, Sai-Ching J., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypercortisolism Manifesting as Severe Weight Loss, Hypokalemia, and Hyperglycemia in the Emergency Department</atitle><jtitle>The Journal of emergency medicine</jtitle><addtitle>J Emerg Med</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>50</volume><issue>4</issue><spage>e187</spage><epage>e190</epage><pages>e187-e190</pages><issn>0736-4679</issn><eissn>2352-5029</eissn><abstract>Abstract Background The concurrence of ectopic adrenocorticotropic hormone (ACTH) syndrome (ectopic Cushing syndrome) and cancer is uncommon in the emergency department (ED) setting, but a constellation of nonspecific signs and symptoms can suggest the presence of Cushing syndrome. 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| subjects | Aged Cushing syndrome Cushing Syndrome - diagnosis Diagnosis, Differential Diagnostic Imaging ectopic Cushing syndrome Emergency Emergency Service, Hospital Female Humans hypercortisolism hyperglycemia Hyperglycemia - diagnosis hypokalemia Hypokalemia - diagnosis lung cancer malignancy Weight Loss |
| title | Hypercortisolism Manifesting as Severe Weight Loss, Hypokalemia, and Hyperglycemia in the Emergency Department |
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