The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells

Abstract Objective While bile acids are important for the digestion process, they also act as signaling molecules in many tissues, including the endocrine pancreas, which expresses specific bile acid receptors that regulate several cell functions. In this study, we investigated the effects of the co...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2016-03, Vol.65 (3), p.54-63
Hauptverfasser:	Vettorazzi, Jean Franciesco, Ribeiro, Rosane Aparecida, Borck, Patricia Cristine, Branco, Renato Chaves Souto, Soriano, Sergi, Merino, Beatriz, Boschero, Antônio Carlos, Nadal, Angel, Quesada, Ivan, Carneiro, Everardo Magalhães
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile acids Calcium Signaling - drug effects Cyclic AMP - physiology Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - physiology Dose-Response Relationship, Drug Endocrinology & Metabolism Glucose - pharmacology In Vitro Techniques Insulin - metabolism Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - secretion KATP Channels - drug effects Male Mice Mice, Inbred C57BL Phosphorylation Protein Kinase Inhibitors - pharmacology Receptors, G-Protein-Coupled - genetics Signal Transduction - drug effects Taurochenodeoxycholic Acid - pharmacology TUDCA β-cell
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