Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models
Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic rev...
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| Veröffentlicht in: | Science China. Life sciences 2016-05, Vol.59 (5), p.480-486 |
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| container_title | Science China. Life sciences |
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| creator | Wang, Li Guan, Jing Wang, Hongyang Lan, Lan Zhang, Qiujing Zong, Liang Du, Wan Xiong, Wenping Li, Fengjiao Wu, Kaiwen Wang, Dayong Wang, Qiuju |
| description | Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future. |
| doi_str_mv | 10.1007/s11427-015-4985-2 |
| format | Article |
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However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-015-4985-2</identifier><identifier>PMID: 26783139</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Animals ; Biomedical and Life Sciences ; Disease Models, Animal ; Hearing Loss, Central - physiopathology ; Life Sciences ; Mice ; Mice, Transgenic ; Research Paper</subject><ispartof>Science China. Life sciences, 2016-05, Vol.59 (5), p.480-486</ispartof><rights>The Author(s) 2016</rights><rights>Science in China Press and Springer-Verlag GmbH 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-dcd4f303f47b4e609d8d441f066258dca0534fd7ca3ce6d3aa64270ce57917b43</citedby><cites>FETCH-LOGICAL-c448t-dcd4f303f47b4e609d8d441f066258dca0534fd7ca3ce6d3aa64270ce57917b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-015-4985-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-015-4985-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26783139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Guan, Jing</creatorcontrib><creatorcontrib>Wang, Hongyang</creatorcontrib><creatorcontrib>Lan, Lan</creatorcontrib><creatorcontrib>Zhang, Qiujing</creatorcontrib><creatorcontrib>Zong, Liang</creatorcontrib><creatorcontrib>Du, Wan</creatorcontrib><creatorcontrib>Xiong, Wenping</creatorcontrib><creatorcontrib>Li, Fengjiao</creatorcontrib><creatorcontrib>Wu, Kaiwen</creatorcontrib><creatorcontrib>Wang, Dayong</creatorcontrib><creatorcontrib>Wang, Qiuju</creatorcontrib><title>Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Disease Models, Animal</subject><subject>Hearing Loss, Central - physiopathology</subject><subject>Life Sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Research Paper</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcFrHCEUxqW0NGGbP6CXIvSSyyS-0VGntxLaJhDopTmL0TfbCTvO1uck7H8ft5uWEgj1oKK_73v6PsbegzgDIcw5AajWNAK6RvW2a9pX7Bis7huwtn9d99qoxkjRHbETojtRh5SiNeYtO2q1sRJkf8zCTYqYqfgUx7TmfoljmfOOJ1zyvPXl547TFkPJy8TjSHOu9CfuOe2o4OTLGHjG-xEf-Jh4yT7RGlM9nOaFsM4RN_SOvRn8hvDkaV2xm69fflxcNtffv11dfL5uglK2NDFENUghB2VuFWrRRxuVgkFo3XY2Bi86qYZogpcBdZTe69oAEbAzPVSJXLHTg-82z78WpOKmkQJuNj5hfY4DC9ALY5X9P2psbzq7b9OKfXyG3s1LTvUjvylQAvS-NhyokGeijIPb5nHyeedAuH1e7pCXq3m5fV6urZoPT87L7YTxr-JPOhVoDwDVq7TG_E_pF10fAWNDoOE</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Wang, Li</creator><creator>Guan, Jing</creator><creator>Wang, Hongyang</creator><creator>Lan, Lan</creator><creator>Zhang, Qiujing</creator><creator>Zong, Liang</creator><creator>Du, Wan</creator><creator>Xiong, Wenping</creator><creator>Li, Fengjiao</creator><creator>Wu, Kaiwen</creator><creator>Wang, Dayong</creator><creator>Wang, Qiuju</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models</title><author>Wang, Li ; Guan, Jing ; Wang, Hongyang ; Lan, Lan ; Zhang, Qiujing ; Zong, Liang ; Du, Wan ; Xiong, Wenping ; Li, Fengjiao ; Wu, Kaiwen ; Wang, Dayong ; Wang, Qiuju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-dcd4f303f47b4e609d8d441f066258dca0534fd7ca3ce6d3aa64270ce57917b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Disease Models, Animal</topic><topic>Hearing Loss, Central - physiopathology</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Guan, Jing</creatorcontrib><creatorcontrib>Wang, Hongyang</creatorcontrib><creatorcontrib>Lan, Lan</creatorcontrib><creatorcontrib>Zhang, Qiujing</creatorcontrib><creatorcontrib>Zong, Liang</creatorcontrib><creatorcontrib>Du, Wan</creatorcontrib><creatorcontrib>Xiong, Wenping</creatorcontrib><creatorcontrib>Li, Fengjiao</creatorcontrib><creatorcontrib>Wu, Kaiwen</creatorcontrib><creatorcontrib>Wang, Dayong</creatorcontrib><creatorcontrib>Wang, Qiuju</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Science China. Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Li</au><au>Guan, Jing</au><au>Wang, Hongyang</au><au>Lan, Lan</au><au>Zhang, Qiujing</au><au>Zong, Liang</au><au>Du, Wan</au><au>Xiong, Wenping</au><au>Li, Fengjiao</au><au>Wu, Kaiwen</au><au>Wang, Dayong</au><au>Wang, Qiuju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>59</volume><issue>5</issue><spage>480</spage><epage>486</epage><pages>480-486</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>Auditory neuropathy spectrum disorder is a unique group of hearing dysfunctions characterized by preserved outer hair cell function and abnormal neural conduction of the auditory pathway. However, the pathogenic mechanism underlying this disorder is not clear. We therefore performed a systematic review of genetic mouse models with different gene mutations to provide a valuable tool for better understanding of the process and the possible molecular mechanisms. Of the 18 articles retrieved, nine met the required criteria. All biochemical, histological, and electrophysiological results were recorded for each of the mouse models, as was the transgenic technology. This review provides a summary of different mouse models that may play an important role in the diagnosis and management of auditory neuropathy spectrum disorder in the future.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>26783139</pmid><doi>10.1007/s11427-015-4985-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Disease Models, Animal Hearing Loss, Central - physiopathology Life Sciences Mice Mice, Transgenic Research Paper |
| title | Understanding auditory neuropathy spectrum disorder: a systematic review in transgenic mouse models |
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