The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release

The conserved Ca(2+)-binding protein Frequenin (homolog of the mammalian NCS-1, neural calcium sensor) is involved in pathologies that result from abnormal synapse number and probability of neurotransmitter release per synapse. Both synaptic features are likely to be co-regulated but the intervening...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of cell science 2014-10, Vol.127 (Pt 19), p.4246-4259
Hauptverfasser:	Romero-Pozuelo, Jesús, Dason, Jeffrey S, Mansilla, Alicia, Baños-Mateos, Soledad, Sardina, José L, Chaves-Sanjuán, Antonio, Jurado-Gómez, Jaime, Santana, Elena, Atwood, Harold L, Hernández-Hernández, Ángel, Sánchez-Barrena, María-José, Ferrús, Alberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - metabolism Crystallography, X-Ray - methods Drosophila Drosophila - metabolism Drosophila Proteins - metabolism Guanine Nucleotide Exchange Factors - metabolism Humans Neuromuscular Junction - metabolism Synaptic Transmission
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!