Anticancer metallohelices: nanomolar potency and high selectivity

A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe 2 L 3 ]Cl 4 · n H 2 O (L = various bidentate ditopic ligands NN-NN) show very good water solubility and stability. Their...

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Veröffentlicht in:	Chemical science (Cambridge) 2016-01, Vol.7 (2), p.951-958
Hauptverfasser:	Kaner, Rebecca A, Allison, Simon J, Faulkner, Alan D, Phillips, Roger M, Roper, David I, Shepherd, Samantha L, Simpson, Daniel H, Waterfield, Nicholas R, Scott, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthamoeba polyphaga Biotechnology Cancer Chemistry Escherichia coli Larvae Manduca sexta Nanostructure Selectivity Self assembly Staphylococcus aureus Toxicity
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