Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein
3-Hydroxypropylmercapturic acid (3-HPMA), a major metabolite of acrolein in urine, has been recognized as a noninvasive biomarker of exposure to cigarette smoke. Since acrolein is formed endogenously from polyamines and is also formed during oxidative stress and aggravates tissue damage by changing...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2016/06/01, Vol.39(6), pp.915-919 |
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| creator | Higashi, Kyohei Igarashi, Kazuei Toida, Toshihiko |
| description | 3-Hydroxypropylmercapturic acid (3-HPMA), a major metabolite of acrolein in urine, has been recognized as a noninvasive biomarker of exposure to cigarette smoke. Since acrolein is formed endogenously from polyamines and is also formed during oxidative stress and aggravates tissue damage by changing protein activity through its conjugation in pathological lesions, it is thought that the urinary 3-HPMA level is useful as a biomarker to monitor the severity of several diseases related to acrolein. To study the correlation between 3-HPMA and disease severity, it is important to understand the properties of analytical methods for determination of 3-HPMA. In this article, we summarize the analytical methods for determination of urinary 3-HPMA and discuss the utility of 3-HPMA as one of the biomarkers for the diagnosis of brain infarction. |
| doi_str_mv | 10.1248/bpb.b15-01022 |
| format | Article |
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Since acrolein is formed endogenously from polyamines and is also formed during oxidative stress and aggravates tissue damage by changing protein activity through its conjugation in pathological lesions, it is thought that the urinary 3-HPMA level is useful as a biomarker to monitor the severity of several diseases related to acrolein. To study the correlation between 3-HPMA and disease severity, it is important to understand the properties of analytical methods for determination of 3-HPMA. In this article, we summarize the analytical methods for determination of urinary 3-HPMA and discuss the utility of 3-HPMA as one of the biomarkers for the diagnosis of brain infarction.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b15-01022</identifier><identifier>PMID: 27251493</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>3-hydroxypropylmercapturic acid (3-HPMA) ; Acetylcysteine - analogs & derivatives ; Acetylcysteine - urine ; acrolein ; Acrolein - metabolism ; Animals ; Biomarkers - urine ; brain infarction ; GC/MS ; Humans ; LC/MS/MS ; Severity of Illness Index ; Stroke - urine</subject><ispartof>Biological and Pharmaceutical Bulletin, 2016/06/01, Vol.39(6), pp.915-919</ispartof><rights>2016 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-7e0a473eba2eec8612c7b46c7df6dfa3dc51657fda4ac703795bcc0e6db8d7fe3</citedby><cites>FETCH-LOGICAL-c735t-7e0a473eba2eec8612c7b46c7df6dfa3dc51657fda4ac703795bcc0e6db8d7fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27251493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Higashi, Kyohei</creatorcontrib><creatorcontrib>Igarashi, Kazuei</creatorcontrib><creatorcontrib>Toida, Toshihiko</creatorcontrib><creatorcontrib>Chiba University</creatorcontrib><creatorcontrib>bAmine Pharma Research Institute</creatorcontrib><creatorcontrib>aGraduate School of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>Innovation Plaza at Chiba University</creatorcontrib><title>Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>3-Hydroxypropylmercapturic acid (3-HPMA), a major metabolite of acrolein in urine, has been recognized as a noninvasive biomarker of exposure to cigarette smoke. 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In this article, we summarize the analytical methods for determination of urinary 3-HPMA and discuss the utility of 3-HPMA as one of the biomarkers for the diagnosis of brain infarction.</description><subject>3-hydroxypropylmercapturic acid (3-HPMA)</subject><subject>Acetylcysteine - analogs & derivatives</subject><subject>Acetylcysteine - urine</subject><subject>acrolein</subject><subject>Acrolein - metabolism</subject><subject>Animals</subject><subject>Biomarkers - urine</subject><subject>brain infarction</subject><subject>GC/MS</subject><subject>Humans</subject><subject>LC/MS/MS</subject><subject>Severity of Illness Index</subject><subject>Stroke - urine</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEokvhyBVZ4sKBFH8kcXxcLbRFagVC9GzZzqT1yrEXO5GaK7-8TlMWiQsHe2TN43fG87oo3hJ8RmjVftIHfaZJXWKCKX1WbAireFlTUj8vNliQtmxI3Z4Ur1LaY4w5puxlcUI5rUkl2Kb4_QMM-BF9j-E2QkrIerT1ys2jNcqhaxjvQpdQHyL6DCPEwXo12uBR6NFNzIc4I1Zezl0M9_MhhsPsBohGHcYpWoO2xnYfkULXap8VsprSwdkRlutbE4MD618XL3rlErx5iqfFzfmXn7vL8urbxdfd9qo0nNVjyQGrijPQigKYtiHUcF01hnd90_WKdaYmTc37TlXKcMy4qLUxGJpOtx3vgZ0WH1bd3OavCdIoB5sMOKc8hClJ0hIiMGsF_z_KBRM412MZff8Pug9TzBNcqbZuKoozVa5UfnNKEXp5iHbIw5MEy8VHmX2U2Uf56GPm3z2pTnqA7kj_MS4DFyuQs4tTwTvr4W9tk7i2wQVJMWkkxrndJeQlliKCCNpw0tJFabcq7dOobuFYSsX8BRw8NsaEbJbt2OAxa-5UlODZAyoiyPg</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Higashi, Kyohei</creator><creator>Igarashi, Kazuei</creator><creator>Toida, Toshihiko</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20160601</creationdate><title>Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein</title><author>Higashi, Kyohei ; 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| subjects | 3-hydroxypropylmercapturic acid (3-HPMA) Acetylcysteine - analogs & derivatives Acetylcysteine - urine acrolein Acrolein - metabolism Animals Biomarkers - urine brain infarction GC/MS Humans LC/MS/MS Severity of Illness Index Stroke - urine |
| title | Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein |
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