Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation
SUMMARY Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunctio...
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| Veröffentlicht in: | Molecular reproduction and development 2016-06, Vol.83 (6), p.470-487 |
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| creator | Martin, Luc J. |
| description | SUMMARY
Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunction of Leydig cells may lead to various male reproductive maladies, including primary hypogonadism, cryptorchidism, and hypospadias. A better understanding of how cell interactions and gene regulation contribute to testicular Leydig cell development and differentiation may therefore help limit the incidence of such male reproductive pathologies. Several hormones and signaling molecules have been identified as important regulators of Leydig cell differentiation and function. Recent work on the regulation of testis development, especially of Leydig cells, has focused on the Desert hedgehog and platelet‐derived growth factor signaling pathways. This review outlines recent findings regarding cell interactions and gene regulation involved in the development and regulation of fetal and adult Leydig cell populations. Mol. Reprod. Dev. 83: 470–487, 2016. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mrd.22648 |
| format | Article |
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Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunction of Leydig cells may lead to various male reproductive maladies, including primary hypogonadism, cryptorchidism, and hypospadias. A better understanding of how cell interactions and gene regulation contribute to testicular Leydig cell development and differentiation may therefore help limit the incidence of such male reproductive pathologies. Several hormones and signaling molecules have been identified as important regulators of Leydig cell differentiation and function. Recent work on the regulation of testis development, especially of Leydig cells, has focused on the Desert hedgehog and platelet‐derived growth factor signaling pathways. This review outlines recent findings regarding cell interactions and gene regulation involved in the development and regulation of fetal and adult Leydig cell populations. Mol. Reprod. Dev. 83: 470–487, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 1040-452X</identifier><identifier>EISSN: 1098-2795</identifier><identifier>DOI: 10.1002/mrd.22648</identifier><identifier>PMID: 27079813</identifier><identifier>CODEN: MREDEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Cell Communication ; Cell Differentiation ; Cryptorchidism - embryology ; Cryptorchidism - pathology ; Gene Expression Regulation ; Humans ; Hypogonadism - embryology ; Hypogonadism - pathology ; Hypospadias - embryology ; Hypospadias - pathology ; Leydig Cells - metabolism ; Leydig Cells - pathology ; Male</subject><ispartof>Molecular reproduction and development, 2016-06, Vol.83 (6), p.470-487</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4598-41c22076e5e589f5614afd0a88971a97e4d970cd10745c81b05bf07e3d4de6ff3</citedby><cites>FETCH-LOGICAL-c4598-41c22076e5e589f5614afd0a88971a97e4d970cd10745c81b05bf07e3d4de6ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrd.22648$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrd.22648$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27079813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Luc J.</creatorcontrib><title>Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation</title><title>Molecular reproduction and development</title><addtitle>Mol. Reprod. Dev</addtitle><description>SUMMARY
Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunction of Leydig cells may lead to various male reproductive maladies, including primary hypogonadism, cryptorchidism, and hypospadias. A better understanding of how cell interactions and gene regulation contribute to testicular Leydig cell development and differentiation may therefore help limit the incidence of such male reproductive pathologies. Several hormones and signaling molecules have been identified as important regulators of Leydig cell differentiation and function. Recent work on the regulation of testis development, especially of Leydig cells, has focused on the Desert hedgehog and platelet‐derived growth factor signaling pathways. This review outlines recent findings regarding cell interactions and gene regulation involved in the development and regulation of fetal and adult Leydig cell populations. Mol. Reprod. Dev. 83: 470–487, 2016. © 2016 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>Cell Communication</subject><subject>Cell Differentiation</subject><subject>Cryptorchidism - embryology</subject><subject>Cryptorchidism - pathology</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Hypogonadism - embryology</subject><subject>Hypogonadism - pathology</subject><subject>Hypospadias - embryology</subject><subject>Hypospadias - pathology</subject><subject>Leydig Cells - metabolism</subject><subject>Leydig Cells - pathology</subject><subject>Male</subject><issn>1040-452X</issn><issn>1098-2795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoqVw4A8gS1zoIe3YsWP7iLZ0i7R8qALBzfLGk8UlH4vtAPvvcXbbHpAQp_FYzzya0VsUzymcUQB23gd3xljN1YPimIJWJZNaPJzfHEou2Nej4kmMNwCgtYLHxRGTILWi1XERFth1xA8Jg22SH4dI7ODIBgdMviEBN1Nn53-SvtlEmnFIwa-nhCSNJGHMUAYCWeHO-Q1pZpvDn9iN2x6HtJc537YYcuf3pqfFo9Z2EZ_d1pPi8-WbT4urcvVh-XbxelU2XOQbOG0YA1mjQKF0K2rKbevAKqUltVoid1pC4yhILhpF1yDWLUisHHdYt211Urw6eLdh_DHlVU3v47ygHXCcoqGKUg0VFfL_qNSaUWCcZ_TlX-jNOIUhHzJTiinJpcrU6YFqwhhjwNZsg-9t2BkKZs7M5MzMPrPMvrg1Tuse3T15F1IGzg_AL9_h7t8m8-764k5ZHiZ8TPj7fsKG76aWlRTmy_ulkR-X11eLi8rU1R9a3bBK</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Martin, Luc J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation</title><author>Martin, Luc J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4598-41c22076e5e589f5614afd0a88971a97e4d970cd10745c81b05bf07e3d4de6ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cell Communication</topic><topic>Cell Differentiation</topic><topic>Cryptorchidism - embryology</topic><topic>Cryptorchidism - pathology</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Hypogonadism - embryology</topic><topic>Hypogonadism - pathology</topic><topic>Hypospadias - embryology</topic><topic>Hypospadias - pathology</topic><topic>Leydig Cells - metabolism</topic><topic>Leydig Cells - pathology</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Luc J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular reproduction and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Luc J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation</atitle><jtitle>Molecular reproduction and development</jtitle><addtitle>Mol. Reprod. Dev</addtitle><date>2016-06</date><risdate>2016</risdate><volume>83</volume><issue>6</issue><spage>470</spage><epage>487</epage><pages>470-487</pages><issn>1040-452X</issn><eissn>1098-2795</eissn><coden>MREDEE</coden><abstract>SUMMARY
Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunction of Leydig cells may lead to various male reproductive maladies, including primary hypogonadism, cryptorchidism, and hypospadias. A better understanding of how cell interactions and gene regulation contribute to testicular Leydig cell development and differentiation may therefore help limit the incidence of such male reproductive pathologies. Several hormones and signaling molecules have been identified as important regulators of Leydig cell differentiation and function. Recent work on the regulation of testis development, especially of Leydig cells, has focused on the Desert hedgehog and platelet‐derived growth factor signaling pathways. This review outlines recent findings regarding cell interactions and gene regulation involved in the development and regulation of fetal and adult Leydig cell populations. Mol. Reprod. Dev. 83: 470–487, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27079813</pmid><doi>10.1002/mrd.22648</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Communication Cell Differentiation Cryptorchidism - embryology Cryptorchidism - pathology Gene Expression Regulation Humans Hypogonadism - embryology Hypogonadism - pathology Hypospadias - embryology Hypospadias - pathology Leydig Cells - metabolism Leydig Cells - pathology Male |
| title | Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation |
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