Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg
Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identi...
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| Veröffentlicht in: | Inflammation 2016-08, Vol.39 (4), p.1462-1468 |
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| container_title | Inflammation |
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| creator | da Silva, Élica Renata Soares Salmazzo, Gustavo Ruivo da Silva Arrigo, Jucicléia Oliveira, Rodrigo Juliano Kassuya, Candida Aparecida Leite Cardoso, Cláudia Andréa Lima |
| description | Campomanesia xanthocarpa
(Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identified for the first time in leaves of the
C. xanthocarpa.
These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test. |
| doi_str_mv | 10.1007/s10753-016-0378-3 |
| format | Article |
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(Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identified for the first time in leaves of the
C. xanthocarpa.
These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-016-0378-3</identifier><identifier>PMID: 27271512</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Brazil ; Cell Movement - drug effects ; Chalcones - isolation & purification ; Chalcones - pharmacology ; Chalcones - therapeutic use ; Chalcones - toxicity ; Edema - drug therapy ; Immunology ; Internal Medicine ; Leukocytes - cytology ; Medicine, Traditional - methods ; Mice ; Myrtaceae ; Myrtaceae - chemistry ; Original Article ; Pathology ; Pharmacology/Toxicology ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Pleural Cavity - metabolism ; Proteins - metabolism ; Rheumatology</subject><ispartof>Inflammation, 2016-08, Vol.39 (4), p.1462-1468</ispartof><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-a9426f8318df89fda6ea22d061a4672a95b1646e9ce800edb4314ebb0f22b4ee3</citedby><cites>FETCH-LOGICAL-c405t-a9426f8318df89fda6ea22d061a4672a95b1646e9ce800edb4314ebb0f22b4ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-016-0378-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-016-0378-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27271512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, Élica Renata Soares</creatorcontrib><creatorcontrib>Salmazzo, Gustavo Ruivo</creatorcontrib><creatorcontrib>da Silva Arrigo, Jucicléia</creatorcontrib><creatorcontrib>Oliveira, Rodrigo Juliano</creatorcontrib><creatorcontrib>Kassuya, Candida Aparecida Leite</creatorcontrib><creatorcontrib>Cardoso, Cláudia Andréa Lima</creatorcontrib><title>Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Campomanesia xanthocarpa
(Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2′,6′-dihydroxy-3′-methyl-4′-metoxychalcone and 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone were identified for the first time in leaves of the
C. xanthocarpa.
These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brazil</subject><subject>Cell Movement - drug effects</subject><subject>Chalcones - isolation & purification</subject><subject>Chalcones - pharmacology</subject><subject>Chalcones - therapeutic use</subject><subject>Chalcones - toxicity</subject><subject>Edema - drug therapy</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Leukocytes - cytology</subject><subject>Medicine, Traditional - methods</subject><subject>Mice</subject><subject>Myrtaceae</subject><subject>Myrtaceae - chemistry</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves - chemistry</subject><subject>Pleural Cavity - metabolism</subject><subject>Proteins - metabolism</subject><subject>Rheumatology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1r3DAQhkVpSbZJfkAvxdBLL0pmJFmSj9sl_YBALinkJsa2vFWwra1kl-y_r4PTUgo5zWGeeWfmYewdwiUCmKuMYErJATUHaSyXr9gGSyO5KI1-zTYgNXBZVeaUvc35AQBsZeUJOxVGGCxRbNj9dpwCD2PX0zDQFNOxuP5F_UxTiGNBY1vcxcfQxD7uQ0N9sR2pP-aQi9gVOxoOcaDR50DFI43Tj9hQOlDxyaf9OXvTUZ_9xXM9Y98_X9_tvvKb2y_fdtsb3igoJ06VErqzEm3b2aprSXsSogWNpLQRVJU1aqV91XgL4NtaSVS-rqETolbeyzP2cc09pPhz9nlyQ8iN7_vlrjhnhxaxAlRCLOiH_9CHOKfloZVCBdbCQuFKNSnmnHznDikMlI4OwT1pd6t2t2h3T9qdXGbePyfP9eDbvxN_PC-AWIG8tMa9T_-sfjH1N8vLjU4</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>da Silva, Élica Renata Soares</creator><creator>Salmazzo, Gustavo Ruivo</creator><creator>da Silva Arrigo, Jucicléia</creator><creator>Oliveira, Rodrigo Juliano</creator><creator>Kassuya, Candida Aparecida Leite</creator><creator>Cardoso, Cláudia Andréa Lima</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160801</creationdate><title>Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg</title><author>da Silva, Élica Renata Soares ; 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C. xanthocarpa.
These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27271512</pmid><doi>10.1007/s10753-016-0378-3</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Brazil Cell Movement - drug effects Chalcones - isolation & purification Chalcones - pharmacology Chalcones - therapeutic use Chalcones - toxicity Edema - drug therapy Immunology Internal Medicine Leukocytes - cytology Medicine, Traditional - methods Mice Myrtaceae Myrtaceae - chemistry Original Article Pathology Pharmacology/Toxicology Plant Extracts - therapeutic use Plant Leaves - chemistry Pleural Cavity - metabolism Proteins - metabolism Rheumatology |
| title | Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg |
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