C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis
We investigated the association of the adipokine C1q/TNF-related protein (CTRP) 1 with coronary artery disease (CAD), and the biological vascular effects of CTRP1. We analysed CTRP1 levels in sera of CAD patients (n = 451) and non-CAD controls (n = 686), and in coronary endarterectomy specimens (n =...
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| Veröffentlicht in: | European heart journal 2016-06, Vol.37 (22), p.1762-1771 |
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| creator | Lu, Lin Zhang, Rui Yan Wang, Xiao Qun Liu, Zhu Hui Shen, Ying Ding, Feng Hua Meng, Hua Wang, Ling Jie Yan, Xiao Xiang Yang, Ke Wang, Hai Bo Pu, Li Jin Zhang, Qi Chen, Qiu Jing De Caterina, Raffaele Shen, Wei Feng |
| description | We investigated the association of the adipokine C1q/TNF-related protein (CTRP) 1 with coronary artery disease (CAD), and the biological vascular effects of CTRP1.
We analysed CTRP1 levels in sera of CAD patients (n = 451) and non-CAD controls (n = 686), and in coronary endarterectomy specimens (n = 32), non-atherosclerotic internal mammary arteries (n = 26), aortic atherosclerotic plaques (n = 15), and non-atherosclerotic aortic samples (n = 10). C1q/TNF-related protein-levels were higher in sera, endarterectomy specimens, aortic atherosclerotic plaques, and peripheral blood mononuclear cells (PBMCs) from CAD patients compared with controls, and were related to CAD severity. The production of CTRP1 was profusely induced by inflammatory cytokines and itself caused a concentration-dependent expression of adhesion molecules and inflammatory markers in human endothelial cells, human peripheral blood monocytes, and THP-1 cells. C1q/TNF-related protein-1 induced p38-dependent monocyte-endothelium adhesion in vitro and the recruitment of leucocytes to mesenteric venules in C57BL/6 mice. Immunohistochemistry of atherosclerotic femoral arteries exhibited CD68 and VE-cadherin loci-associated increased CTRP1 expression in plaques. Compared with saline, intraperitoneal injection of recombinant CTRP1 protein (200 μg/kg) every other day promoted atherogenesis in apoE(-/-) mice at 24 weeks. However, pro-atherogenic effects were significantly attenuated in CTRP1(-/-)/apoE(-/-) double-knockout mice compared with apoE(-/-) mice, with a consistent decrease in vascular adhesion molecule, phospho-p38 and TNF-α expression and macrophage infiltration in plaque in CTRP1(-/-) and double-knockout mice. Tumour necrosis factor-α-induced expression of adhesion molecules and cytokines were lower in primary endothelial cells and macrophages from CTRP(-/-) mice than in those from C57BL/6 mice.
C1q/TNF-related protein-1 is a marker of atherosclerosis in humans and promotes atherogenesis in mice. |
| doi_str_mv | 10.1093/eurheartj/ehv649 |
| format | Article |
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We analysed CTRP1 levels in sera of CAD patients (n = 451) and non-CAD controls (n = 686), and in coronary endarterectomy specimens (n = 32), non-atherosclerotic internal mammary arteries (n = 26), aortic atherosclerotic plaques (n = 15), and non-atherosclerotic aortic samples (n = 10). C1q/TNF-related protein-levels were higher in sera, endarterectomy specimens, aortic atherosclerotic plaques, and peripheral blood mononuclear cells (PBMCs) from CAD patients compared with controls, and were related to CAD severity. The production of CTRP1 was profusely induced by inflammatory cytokines and itself caused a concentration-dependent expression of adhesion molecules and inflammatory markers in human endothelial cells, human peripheral blood monocytes, and THP-1 cells. C1q/TNF-related protein-1 induced p38-dependent monocyte-endothelium adhesion in vitro and the recruitment of leucocytes to mesenteric venules in C57BL/6 mice. Immunohistochemistry of atherosclerotic femoral arteries exhibited CD68 and VE-cadherin loci-associated increased CTRP1 expression in plaques. Compared with saline, intraperitoneal injection of recombinant CTRP1 protein (200 μg/kg) every other day promoted atherogenesis in apoE(-/-) mice at 24 weeks. However, pro-atherogenic effects were significantly attenuated in CTRP1(-/-)/apoE(-/-) double-knockout mice compared with apoE(-/-) mice, with a consistent decrease in vascular adhesion molecule, phospho-p38 and TNF-α expression and macrophage infiltration in plaque in CTRP1(-/-) and double-knockout mice. Tumour necrosis factor-α-induced expression of adhesion molecules and cytokines were lower in primary endothelial cells and macrophages from CTRP(-/-) mice than in those from C57BL/6 mice.
C1q/TNF-related protein-1 is a marker of atherosclerosis in humans and promotes atherogenesis in mice.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehv649</identifier><identifier>PMID: 26705391</identifier><language>eng</language><publisher>England</publisher><subject>Adipokines ; Animals ; Antigens, CD ; Apolipoproteins E ; Atherosclerosis ; Cadherins ; Humans ; Leukocytes, Mononuclear ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proteins</subject><ispartof>European heart journal, 2016-06, Vol.37 (22), p.1762-1771</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-e602f7ced77024458fb8cd668a936008515a2735cacfe481f6f111d9f59f195c3</citedby><cites>FETCH-LOGICAL-c440t-e602f7ced77024458fb8cd668a936008515a2735cacfe481f6f111d9f59f195c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26705391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Zhang, Rui Yan</creatorcontrib><creatorcontrib>Wang, Xiao Qun</creatorcontrib><creatorcontrib>Liu, Zhu Hui</creatorcontrib><creatorcontrib>Shen, Ying</creatorcontrib><creatorcontrib>Ding, Feng Hua</creatorcontrib><creatorcontrib>Meng, Hua</creatorcontrib><creatorcontrib>Wang, Ling Jie</creatorcontrib><creatorcontrib>Yan, Xiao Xiang</creatorcontrib><creatorcontrib>Yang, Ke</creatorcontrib><creatorcontrib>Wang, Hai Bo</creatorcontrib><creatorcontrib>Pu, Li Jin</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Chen, Qiu Jing</creatorcontrib><creatorcontrib>De Caterina, Raffaele</creatorcontrib><creatorcontrib>Shen, Wei Feng</creatorcontrib><title>C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>We investigated the association of the adipokine C1q/TNF-related protein (CTRP) 1 with coronary artery disease (CAD), and the biological vascular effects of CTRP1.
We analysed CTRP1 levels in sera of CAD patients (n = 451) and non-CAD controls (n = 686), and in coronary endarterectomy specimens (n = 32), non-atherosclerotic internal mammary arteries (n = 26), aortic atherosclerotic plaques (n = 15), and non-atherosclerotic aortic samples (n = 10). C1q/TNF-related protein-levels were higher in sera, endarterectomy specimens, aortic atherosclerotic plaques, and peripheral blood mononuclear cells (PBMCs) from CAD patients compared with controls, and were related to CAD severity. The production of CTRP1 was profusely induced by inflammatory cytokines and itself caused a concentration-dependent expression of adhesion molecules and inflammatory markers in human endothelial cells, human peripheral blood monocytes, and THP-1 cells. C1q/TNF-related protein-1 induced p38-dependent monocyte-endothelium adhesion in vitro and the recruitment of leucocytes to mesenteric venules in C57BL/6 mice. Immunohistochemistry of atherosclerotic femoral arteries exhibited CD68 and VE-cadherin loci-associated increased CTRP1 expression in plaques. Compared with saline, intraperitoneal injection of recombinant CTRP1 protein (200 μg/kg) every other day promoted atherogenesis in apoE(-/-) mice at 24 weeks. However, pro-atherogenic effects were significantly attenuated in CTRP1(-/-)/apoE(-/-) double-knockout mice compared with apoE(-/-) mice, with a consistent decrease in vascular adhesion molecule, phospho-p38 and TNF-α expression and macrophage infiltration in plaque in CTRP1(-/-) and double-knockout mice. Tumour necrosis factor-α-induced expression of adhesion molecules and cytokines were lower in primary endothelial cells and macrophages from CTRP(-/-) mice than in those from C57BL/6 mice.
C1q/TNF-related protein-1 is a marker of atherosclerosis in humans and promotes atherogenesis in mice.</description><subject>Adipokines</subject><subject>Animals</subject><subject>Antigens, CD</subject><subject>Apolipoproteins E</subject><subject>Atherosclerosis</subject><subject>Cadherins</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Proteins</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUMtOwzAQtBCIlsKdE8qRS6g38SPmhioKSAUuReIWuc6apuTR2gkSf4_bQq9cdrSrmdXMEHIJ9AaoSsfYuyVq163GuPwSTB2RIfAkiZVg_JgMKSgeC5G9D8iZ9ytKaSZAnJJBIiTlqYIheZ7AZjx_mcYOK91hEa1d22HZxHAb6SbSRbluP8sGo1q7gB_huOPUbbfbuiW61ptqO0t_Tk6srjxe_OKIvE3v55PHePb68DS5m8WGMdrFKGhipcFCSpowxjO7yEwRjGqVimCSA9eJTLnRxiLLwAoLAIWyXNkQyaQjcr3_G5xsevRdXpfeYFXpBtve55ABKEolS_6nSsUzIVO6pdI91YQw3qHN164Mub9zoPm27_zQd77vO0iufr_3ixqLg-Cv4PQHTch-XQ</recordid><startdate>20160607</startdate><enddate>20160607</enddate><creator>Lu, Lin</creator><creator>Zhang, Rui Yan</creator><creator>Wang, Xiao Qun</creator><creator>Liu, Zhu Hui</creator><creator>Shen, Ying</creator><creator>Ding, Feng Hua</creator><creator>Meng, Hua</creator><creator>Wang, Ling Jie</creator><creator>Yan, Xiao Xiang</creator><creator>Yang, Ke</creator><creator>Wang, Hai Bo</creator><creator>Pu, Li Jin</creator><creator>Zhang, Qi</creator><creator>Chen, Qiu Jing</creator><creator>De Caterina, Raffaele</creator><creator>Shen, Wei Feng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20160607</creationdate><title>C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis</title><author>Lu, Lin ; Zhang, Rui Yan ; Wang, Xiao Qun ; Liu, Zhu Hui ; Shen, Ying ; Ding, Feng Hua ; Meng, Hua ; Wang, Ling Jie ; Yan, Xiao Xiang ; Yang, Ke ; Wang, Hai Bo ; Pu, Li Jin ; Zhang, Qi ; Chen, Qiu Jing ; De Caterina, Raffaele ; Shen, Wei Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-e602f7ced77024458fb8cd668a936008515a2735cacfe481f6f111d9f59f195c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipokines</topic><topic>Animals</topic><topic>Antigens, CD</topic><topic>Apolipoproteins E</topic><topic>Atherosclerosis</topic><topic>Cadherins</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Lin</creatorcontrib><creatorcontrib>Zhang, Rui Yan</creatorcontrib><creatorcontrib>Wang, Xiao Qun</creatorcontrib><creatorcontrib>Liu, Zhu Hui</creatorcontrib><creatorcontrib>Shen, Ying</creatorcontrib><creatorcontrib>Ding, Feng Hua</creatorcontrib><creatorcontrib>Meng, Hua</creatorcontrib><creatorcontrib>Wang, Ling Jie</creatorcontrib><creatorcontrib>Yan, Xiao Xiang</creatorcontrib><creatorcontrib>Yang, Ke</creatorcontrib><creatorcontrib>Wang, Hai Bo</creatorcontrib><creatorcontrib>Pu, Li Jin</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Chen, Qiu Jing</creatorcontrib><creatorcontrib>De Caterina, Raffaele</creatorcontrib><creatorcontrib>Shen, Wei Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Lin</au><au>Zhang, Rui Yan</au><au>Wang, Xiao Qun</au><au>Liu, Zhu Hui</au><au>Shen, Ying</au><au>Ding, Feng Hua</au><au>Meng, Hua</au><au>Wang, Ling Jie</au><au>Yan, Xiao Xiang</au><au>Yang, Ke</au><au>Wang, Hai Bo</au><au>Pu, Li Jin</au><au>Zhang, Qi</au><au>Chen, Qiu Jing</au><au>De Caterina, Raffaele</au><au>Shen, Wei Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2016-06-07</date><risdate>2016</risdate><volume>37</volume><issue>22</issue><spage>1762</spage><epage>1771</epage><pages>1762-1771</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>We investigated the association of the adipokine C1q/TNF-related protein (CTRP) 1 with coronary artery disease (CAD), and the biological vascular effects of CTRP1.
We analysed CTRP1 levels in sera of CAD patients (n = 451) and non-CAD controls (n = 686), and in coronary endarterectomy specimens (n = 32), non-atherosclerotic internal mammary arteries (n = 26), aortic atherosclerotic plaques (n = 15), and non-atherosclerotic aortic samples (n = 10). C1q/TNF-related protein-levels were higher in sera, endarterectomy specimens, aortic atherosclerotic plaques, and peripheral blood mononuclear cells (PBMCs) from CAD patients compared with controls, and were related to CAD severity. The production of CTRP1 was profusely induced by inflammatory cytokines and itself caused a concentration-dependent expression of adhesion molecules and inflammatory markers in human endothelial cells, human peripheral blood monocytes, and THP-1 cells. C1q/TNF-related protein-1 induced p38-dependent monocyte-endothelium adhesion in vitro and the recruitment of leucocytes to mesenteric venules in C57BL/6 mice. Immunohistochemistry of atherosclerotic femoral arteries exhibited CD68 and VE-cadherin loci-associated increased CTRP1 expression in plaques. Compared with saline, intraperitoneal injection of recombinant CTRP1 protein (200 μg/kg) every other day promoted atherogenesis in apoE(-/-) mice at 24 weeks. However, pro-atherogenic effects were significantly attenuated in CTRP1(-/-)/apoE(-/-) double-knockout mice compared with apoE(-/-) mice, with a consistent decrease in vascular adhesion molecule, phospho-p38 and TNF-α expression and macrophage infiltration in plaque in CTRP1(-/-) and double-knockout mice. Tumour necrosis factor-α-induced expression of adhesion molecules and cytokines were lower in primary endothelial cells and macrophages from CTRP(-/-) mice than in those from C57BL/6 mice.
C1q/TNF-related protein-1 is a marker of atherosclerosis in humans and promotes atherogenesis in mice.</abstract><cop>England</cop><pmid>26705391</pmid><doi>10.1093/eurheartj/ehv649</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adipokines Animals Antigens, CD Apolipoproteins E Atherosclerosis Cadherins Humans Leukocytes, Mononuclear Mice Mice, Inbred C57BL Mice, Knockout Proteins |
| title | C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis |
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