Applying theoretical premises of binary toxicity mathematical modeling to combined impacts of chemical plus physical agents (A case study of moderate subchronic exposures to fluoride and static magnetic field)

Sodium fluoride solution was injected i.p. to rats at a dose equivalent to 0.1 LD50 three times a week up to 18 injections. Two thirds of these rats and of the sham-injected ones were exposed to the whole body impact of a 25 mT static magnetic field for 2 or 4 h a day, 5 times a week. For mathematic...

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Veröffentlicht in:Food and chemical toxicology 2016-09, Vol.95, p.110-120
Hauptverfasser: Katsnelson, B.A., Tsepilov, N.A., Panov, V.G., Sutunkova, M.P., Varaksin, A.N., Gurvich, V.B., Minigalieva, I.A., Valamina, I.E., Makeyev, O.H., Meshtcheryakova, E.Y.
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container_end_page 120
container_issue
container_start_page 110
container_title Food and chemical toxicology
container_volume 95
creator Katsnelson, B.A.
Tsepilov, N.A.
Panov, V.G.
Sutunkova, M.P.
Varaksin, A.N.
Gurvich, V.B.
Minigalieva, I.A.
Valamina, I.E.
Makeyev, O.H.
Meshtcheryakova, E.Y.
description Sodium fluoride solution was injected i.p. to rats at a dose equivalent to 0.1 LD50 three times a week up to 18 injections. Two thirds of these rats and of the sham-injected ones were exposed to the whole body impact of a 25 mT static magnetic field for 2 or 4 h a day, 5 times a week. For mathematical analysis of the effects they produced in combination, we used a response surface model. This analysis demonstrated that (like in combined toxicity) the combined adverse action of a chemical plus a physical agent was characterized by a diversity of types depending not only on particular effects these types were assessed for but on their level as well. From this point of view, the indices for which at least one statistically significant effect was observed could be classified as identifying (1) single-factor action; (2) additivity; (3) synergism; (4) antagonism (both subadditive unidirectional action and all variants of contradirectional action). Although the classes (2) and (3) taken together encompass a smaller part of the indices, the biological importance of some of them renders the combination of agents studied as posing a higher health risk than that associated with each them acting alone. •Rats were exposed to repeated i.p. injections of NaF and/or to 2 or 4 h impact of static magnetic field with induction 25 mT.•The analysis revealed a diversity of the combined action type depending on the effect it was assessed for.•In toto, combined NaF-magnetic field exposure is more hazardous comparing with that to any of the agent separately.
doi_str_mv 10.1016/j.fct.2016.06.024
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subjects Animals
Combined adverse action
Drug Evaluation
Female
Fluoride
Magnetic Fields - adverse effects
Models, Theoretical
Rats
Risk Assessment
Sodium Fluoride - toxicity
Static magnetic field
Toxicity Tests, Subchronic - methods
title Applying theoretical premises of binary toxicity mathematical modeling to combined impacts of chemical plus physical agents (A case study of moderate subchronic exposures to fluoride and static magnetic field)
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