Epigallocatechin‐3‐Gallate Inhibits Ethanol‐Induced Apoptosis Through Neurod1 Regulating CHOP Expression in Pancreatic β‐Cells

ABSTRACT Epiga‐llocatechin‐3‐gallate (EGCG) is one kind of polyphenol abundant extracted from green tea which has a potent antidiabetic activity. However, the molecular mechanisms mediating the protection procession of EGCG are still unclear. The aim of this study was to investigate the protective e...

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Veröffentlicht in:	Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2016-05, Vol.299 (5), p.573-582
Hauptverfasser:	Wu, Tijun, Xiang, Jie, Shan, Wei, Li, Mengxiao, Zhou, Wenbo, Han, Xiao, Chen, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Blotting, Western Catechin - analogs & derivatives Catechin - pharmacology Cell Proliferation Cells, Cultured Central Nervous System Depressants - pharmacology CHOP Chromatin Immunoprecipitation EGCG ethanol Ethanol - pharmacology Gene Expression Regulation - drug effects Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurod1 Neuroprotective Agents - pharmacology Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism β‐cells
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