Formation and removal of poly‐ubiquitin chains in the regulation of tumor necrosis factor‐induced gene activation and cell death

Tumor necrosis factor (TNF) is a potent cytokine known for its involvement in inflammation, repression of tumorigenesis and activation of immune cells. Consequently, accurate regulation of the TNF signaling pathway is crucial for preventing the potent noxious effects of TNF. These pathological condi...

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Veröffentlicht in:	The FEBS journal 2016-07, Vol.283 (14), p.2626-2639
Hauptverfasser:	Kupka, Sebastian, Reichert, Matthias, Draber, Peter, Walczak, Henning
Format:	Artikel
Sprache:	eng
Schlagworte:	A20 Animals Apoptosis cell death Cell Death - genetics Cell Death - physiology CYLD Deubiquitinating Enzyme CYLD Endopeptidases - metabolism Genetics HOIL‐1 HOIP Humans Kinases LUBAC Models, Biological OTULIN Polyubiquitin - metabolism Protein Multimerization Proteins Receptors, Tumor Necrosis Factor, Type I - chemistry Receptors, Tumor Necrosis Factor, Type I - metabolism SHARPIN Signal Transduction TNFR1 Transcriptional Activation Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism Tumor necrosis factor-TNF Tumor Necrosis Factors - metabolism Tumor Suppressor Proteins - metabolism Ubiquitin Ubiquitination
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