Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder

•NOX2 activation leads to ROS overproduction in a rat model of PTSD.•Excessive oxidative stress elicits phenotype loss of PV interneurons.•Phenotype loss of PV interneurons might contribute to abnormal behaviors in this PTSD model.•EE reverses all these abnormalities in this PTSD model. Post-traumat...

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Veröffentlicht in:	Behavioural brain research 2016-10, Vol.312, p.84-92
Hauptverfasser:	Sun, Xiao R., Zhang, Hui, Zhao, Hong T., Ji, Mu H., Li, Hui H., Wu, Jing, Li, Kuan Y., Yang, Jian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety Conditioning, Classical Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Disease Models, Animal Electroshock Environment Environmental enrichment Fear GABAergic Neurons - metabolism Glutamate Decarboxylase - metabolism Hippocampus - metabolism Interneurons - metabolism Male Maze Learning NADP - metabolism NADPH Oxidase 2 - metabolism NADPH Oxidase 4 - metabolism Oxidative Stress Parvalbumin Parvalbumins - metabolism Phenotype Post-traumatic stress disorder Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species Spatial Memory Stress Disorders, Post-Traumatic - metabolism Stress Disorders, Post-Traumatic - prevention & control Stress Disorders, Post-Traumatic - psychology
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