Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists

Piperine is an alkaloid responsible for the pungency of black pepper. In this study, piperine isolated from Piper nigrum L. was hydrolyzed under basic condition to obtain piperic acid and was used as precursor to carry out the synthesis of twenty piperine derivatives containing benzothiazole moiety....

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Veröffentlicht in:	Chemical biology & drug design 2016-09, Vol.88 (3), p.354-362
Hauptverfasser:	Kharbanda, Chetna, Alam, Mohammad Sarwar, Hamid, Hinna, Javed, Kalim, Bano, Sameena, Ali, Yakub, Dhulap, Abhijeet, Alam, Perwez, Pasha, M. A. Qadar
Format:	Artikel
Sprache:	eng
Schlagworte:	amide linkage Animals antidiabetic Blood Glucose - analysis Blood Glucose - metabolism Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism gene expression Gene Expression Regulation - drug effects HEK293 Cells Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Lipid Peroxidation - drug effects Male Molecular Docking Simulation Piper nigrum Piper nigrum - chemistry Piperidines - chemistry Piperidines - pharmacology Piperidines - therapeutic use piperine PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism PPAR-γ Rats, Wistar
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