Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression

In major depressive disorder (MDD), single nucleotide polymorphisms (SNPs) in monoaminergic genes may impact disease susceptibility, treatment response, and brain volume. The objective of this study was to examine the effect of such polymorphisms on hippocampal volume in patients with treatment-resi...

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Veröffentlicht in:	Acta neuropsychiatrica 2015-12, Vol.27 (6), p.353-361
Hauptverfasser:	Phillips, Jennifer Lynne, Batten, Lisa Ann, Tremblay, Philippe, Aldosary, Fahad, Du, Lisheng, Blier, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Alleles Antidepressants Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Catechol O-Methyltransferase - genetics Catechol O-Methyltransferase - metabolism Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Depressive Disorder, Treatment-Resistant - genetics Depressive Disorder, Treatment-Resistant - metabolism Depressive Disorder, Treatment-Resistant - pathology Emotional disorders Female Genes Genotype Genotype & phenotype Handedness Hippocampus - metabolism Hippocampus - pathology Homozygote Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Mental depression Mental disorders Mental health Middle Aged Mood disorders Norepinephrine Plasma Membrane Transport Proteins - genetics Norepinephrine Plasma Membrane Transport Proteins - metabolism Original Articles Patients Polymorphism Polymorphism, Single Nucleotide Receptor, Serotonin, 5-HT1A - genetics Receptor, Serotonin, 5-HT1A - metabolism Remission (Medicine) Scanners Serotonin Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Signal transduction
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