Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor

Synovial sarcoma is a soft‐tissue sarcoma and a rare type of cancer. Unfortunately, effective chemotherapies for synovial sarcomas have not been established. In this report, we show that synovial sarcoma cell lines have reduced repair activity for DNA damage induced by ionizing radiation (IR) and a...

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Veröffentlicht in:	Genes to cells : devoted to molecular & cellular mechanisms 2016-08, Vol.21 (8), p.852-860
Hauptverfasser:	Yamasaki, Hiroyuki, Miyamoto, Mamiko, Yamamoto, Yuki, Kondo, Tadashi, Watanabe, Toshiki, Ohta, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Dacarbazine - administration & dosage Dacarbazine - analogs & derivatives DNA Damage - drug effects DNA Damage - genetics DNA Damage - radiation effects DNA Repair - drug effects DNA Repair - genetics DNA Repair - radiation effects Etoposide - administration & dosage Humans Phthalazines - administration & dosage Piperazines - administration & dosage Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage Radiation, Ionizing Recombinational DNA Repair - genetics Sarcoma, Synovial - drug therapy Sarcoma, Synovial - genetics Sarcoma, Synovial - pathology Topoisomerase II Inhibitors - administration & dosage
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