Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas
Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tum...
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| Veröffentlicht in: | Cancer genomics & proteomics 2015-05, Vol.12 (3), p.113-118 |
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| container_title | Cancer genomics & proteomics |
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| creator | Jia, Wang Zhu, Jinkui Martin, Tracey A Sanders, Andrew J Yang, Xiaomei Cheng, Shan Yu, Hefen Jia, Guijun Liu, Xiao Lu, Runchun Jiang, Wen G |
| description | Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells.
In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors.
MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p |
| format | Article |
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In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors.
MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors.
MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.</description><identifier>ISSN: 1109-6535</identifier><identifier>EISSN: 1790-6245</identifier><identifier>PMID: 25977170</identifier><language>eng</language><publisher>Greece</publisher><subject>Adenoma - genetics ; Adenoma - pathology ; Adult ; Aged ; Female ; Gene Expression Regulation, Neoplastic ; Histone Deacetylases - genetics ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Pituitary Neoplasms - diagnosis ; Pituitary Neoplasms - genetics ; Pituitary Neoplasms - pathology ; Repressor Proteins - genetics ; Trans-Activators ; Tumor Burden</subject><ispartof>Cancer genomics & proteomics, 2015-05, Vol.12 (3), p.113-118</ispartof><rights>Copyright© 2015, International Institute of Anticancer Research (Dr. John G. Delinasios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25977170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Wang</creatorcontrib><creatorcontrib>Zhu, Jinkui</creatorcontrib><creatorcontrib>Martin, Tracey A</creatorcontrib><creatorcontrib>Sanders, Andrew J</creatorcontrib><creatorcontrib>Yang, Xiaomei</creatorcontrib><creatorcontrib>Cheng, Shan</creatorcontrib><creatorcontrib>Yu, Hefen</creatorcontrib><creatorcontrib>Jia, Guijun</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Lu, Runchun</creatorcontrib><creatorcontrib>Jiang, Wen G</creatorcontrib><title>Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas</title><title>Cancer genomics & proteomics</title><addtitle>Cancer Genomics Proteomics</addtitle><description>Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells.
In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors.
MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors.
MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.</description><subject>Adenoma - genetics</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Histone Deacetylases - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pituitary Neoplasms - diagnosis</subject><subject>Pituitary Neoplasms - genetics</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Repressor Proteins - genetics</subject><subject>Trans-Activators</subject><subject>Tumor Burden</subject><issn>1109-6535</issn><issn>1790-6245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE9LxDAQxYMo7rr6FSRHL4GkaZvkKMv6Bxa86LmkzWQ30iS1SV399lZdQRh4M_MeP4Y5QUsmFCV1UVanc8-oInXFqwW6SOmV0lLwkp6jRVEpIZigS3TYfAwjpORiwNFiD1mnuVwiOqXYOZ3B4B0EIAy7hP8tDy7vcRsDYBfe9Q9AB4Pz5OOIZ8bu28D7yeuAB5cnl_X4ibWBEL1Ol-jM6j7B1VFX6OVu87x-INun-8f17ZYMBWOZ1LbtONdCcgMdB8OpZJq2dScplBVAobgodGmEkqq1xljJadvNA1dgJVi-Qje_3GGMbxOk3HiXOuh7HSBOqWGSMSlVqeQcvT5Gp9aDaYbR-fnk5u9Z_AvDxGm1</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Jia, Wang</creator><creator>Zhu, Jinkui</creator><creator>Martin, Tracey A</creator><creator>Sanders, Andrew J</creator><creator>Yang, Xiaomei</creator><creator>Cheng, Shan</creator><creator>Yu, Hefen</creator><creator>Jia, Guijun</creator><creator>Liu, Xiao</creator><creator>Lu, Runchun</creator><creator>Jiang, Wen G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20150501</creationdate><title>Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas</title><author>Jia, Wang ; Zhu, Jinkui ; Martin, Tracey A ; Sanders, Andrew J ; Yang, Xiaomei ; Cheng, Shan ; Yu, Hefen ; Jia, Guijun ; Liu, Xiao ; Lu, Runchun ; Jiang, Wen G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-6fbc33a783dec3ed3081a0b6c80e45ee29372a4d7989bfddf830bc98939ef8ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenoma - genetics</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Histone Deacetylases - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pituitary Neoplasms - diagnosis</topic><topic>Pituitary Neoplasms - genetics</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Repressor Proteins - genetics</topic><topic>Trans-Activators</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Wang</creatorcontrib><creatorcontrib>Zhu, Jinkui</creatorcontrib><creatorcontrib>Martin, Tracey A</creatorcontrib><creatorcontrib>Sanders, Andrew J</creatorcontrib><creatorcontrib>Yang, Xiaomei</creatorcontrib><creatorcontrib>Cheng, Shan</creatorcontrib><creatorcontrib>Yu, Hefen</creatorcontrib><creatorcontrib>Jia, Guijun</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Lu, Runchun</creatorcontrib><creatorcontrib>Jiang, Wen G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer genomics & proteomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Wang</au><au>Zhu, Jinkui</au><au>Martin, Tracey A</au><au>Sanders, Andrew J</au><au>Yang, Xiaomei</au><au>Cheng, Shan</au><au>Yu, Hefen</au><au>Jia, Guijun</au><au>Liu, Xiao</au><au>Lu, Runchun</au><au>Jiang, Wen G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas</atitle><jtitle>Cancer genomics & proteomics</jtitle><addtitle>Cancer Genomics Proteomics</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>12</volume><issue>3</issue><spage>113</spage><epage>118</epage><pages>113-118</pages><issn>1109-6535</issn><eissn>1790-6245</eissn><abstract>Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells.
In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors.
MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors.
MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.</abstract><cop>Greece</cop><pmid>25977170</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adenoma - genetics Adenoma - pathology Adult Aged Female Gene Expression Regulation, Neoplastic Histone Deacetylases - genetics Humans Male Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Pituitary Neoplasms - diagnosis Pituitary Neoplasms - genetics Pituitary Neoplasms - pathology Repressor Proteins - genetics Trans-Activators Tumor Burden |
| title | Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas |
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