The DNA damage response molecule MCPH1 in brain development and beyond

Microcephalin （MCPH1） is identified as being responsible for the neurodevelopmental disorder pri- mary microcephaly type 1, which is characterized by a smaller-than-normal brain size and mental retardation. MCPH1 has originally been identified as an important regulator of telomere integrity and of c...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2016-07, Vol.48 (7), p.678-685
Hauptverfasser:	Liu, Xiaoqian, Zhou, Zhong-Wei, Wang, Zhao-Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - embryology Carcinogenesis Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - physiology DNA Damage DNA损伤 Humans Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology RNA, Messenger - genetics 分子反应大脑发育神经前体细胞细胞周期控制细胞周期调控肿瘤抑制基因
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