The DNA damage response molecule MCPH1 in brain development and beyond
Microcephalin （MCPH1） is identified as being responsible for the neurodevelopmental disorder pri- mary microcephaly type 1, which is characterized by a smaller-than-normal brain size and mental retardation. MCPH1 has originally been identified as an important regulator of telomere integrity and of c...
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| Veröffentlicht in: | Acta biochimica et biophysica Sinica 2016-07, Vol.48 (7), p.678-685 |
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| creator | Liu, Xiaoqian Zhou, Zhong-Wei Wang, Zhao-Qi |
| description | Microcephalin （MCPH1） is identified as being responsible for the neurodevelopmental disorder pri- mary microcephaly type 1, which is characterized by a smaller-than-normal brain size and mental retardation. MCPH1 has originally been identified as an important regulator of telomere integrity and of cell cycle control. Genetic and cellular studies show that MCPH1 controls neurogenesis by coordinating the cell cycle and the centrosome cycle and thereby regulating the division mode of neuroprogenitors to prevent the exhaustion of the progenitor pool and thereby microcephaly. In addition to its role in neurogenesis, MCPH1 plays a role in gonad development. MCPH1 also func- tions as a tumor suppressor in several human cancers as well as in mouse models. Here, we review the role of MCPH1 in DNA damage response, cell cycle control, chromosome condensation and chromatin remodeling. We also summarize the studies on the biological functions of MCPH1 in brain size determination and in pathologies, including infertility and cancer. |
| doi_str_mv | 10.1093/abbs/gmw048 |
| format | Article |
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MCPH1 has originally been identified as an important regulator of telomere integrity and of cell cycle control. Genetic and cellular studies show that MCPH1 controls neurogenesis by coordinating the cell cycle and the centrosome cycle and thereby regulating the division mode of neuroprogenitors to prevent the exhaustion of the progenitor pool and thereby microcephaly. In addition to its role in neurogenesis, MCPH1 plays a role in gonad development. MCPH1 also func- tions as a tumor suppressor in several human cancers as well as in mouse models. Here, we review the role of MCPH1 in DNA damage response, cell cycle control, chromosome condensation and chromatin remodeling. We also summarize the studies on the biological functions of MCPH1 in brain size determination and in pathologies, including infertility and cancer.</description><identifier>ISSN: 1672-9145</identifier><identifier>EISSN: 1745-7270</identifier><identifier>DOI: 10.1093/abbs/gmw048</identifier><identifier>PMID: 27197793</identifier><language>eng</language><publisher>China</publisher><subject>Animals ; Brain - embryology ; Carcinogenesis ; Chromosomal Proteins, Non-Histone - genetics ; Chromosomal Proteins, Non-Histone - physiology ; DNA Damage ; DNA损伤 ; Humans ; Mice ; Mice, Knockout ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; RNA, Messenger - genetics ; 分子 ; 反应 ; 大脑发育 ; 神经前体细胞 ; 细胞周期控制 ; 细胞周期调控 ; 肿瘤抑制基因</subject><ispartof>Acta biochimica et biophysica Sinica, 2016-07, Vol.48 (7), p.678-685</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. All rights reserved. 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MCPH1 has originally been identified as an important regulator of telomere integrity and of cell cycle control. Genetic and cellular studies show that MCPH1 controls neurogenesis by coordinating the cell cycle and the centrosome cycle and thereby regulating the division mode of neuroprogenitors to prevent the exhaustion of the progenitor pool and thereby microcephaly. In addition to its role in neurogenesis, MCPH1 plays a role in gonad development. MCPH1 also func- tions as a tumor suppressor in several human cancers as well as in mouse models. Here, we review the role of MCPH1 in DNA damage response, cell cycle control, chromosome condensation and chromatin remodeling. We also summarize the studies on the biological functions of MCPH1 in brain size determination and in pathologies, including infertility and cancer.</description><subject>Animals</subject><subject>Brain - embryology</subject><subject>Carcinogenesis</subject><subject>Chromosomal Proteins, Non-Histone - genetics</subject><subject>Chromosomal Proteins, Non-Histone - physiology</subject><subject>DNA Damage</subject><subject>DNA损伤</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>RNA, Messenger - genetics</subject><subject>分子</subject><subject>反应</subject><subject>大脑发育</subject><subject>神经前体细胞</subject><subject>细胞周期控制</subject><subject>细胞周期调控</subject><subject>肿瘤抑制基因</subject><issn>1672-9145</issn><issn>1745-7270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1PwzAQQC0EoqUwsSOLCQmFnu3EjseqUIpUPoYyR3Z8aYPy1bgF9d-TqqUzy90NT294R8g1gwcGWgyNtX64KH8gjE9In6kwChRXcNrdUvFAszDqkQvvvwCElAzOSY8rppXSok8m8yXSx7cRdaY0C6Qt-qauPNKyLjDdFEhfxx9TRvOK2tZ00-E3FnVTYrWmpnLU4rau3CU5y0zh8eqwB-Rz8jQfT4PZ-_PLeDQLUhHqdSCNAm14lqY2UlEYh8qaSCspAXRkTczQZS5G4KCsjZlwmVZCaQYpGOe4EQNyt_c2bb3aoF8nZe5TLApTYb3xCYsZi2PFOf8HCiwUnGvWofd7NG1r71vMkqbNS9NuEwbJrnGya5zsG3f0zUG8sSW6I_sXtQNuD7plXS1WebU4MlLq7idSgfgFZyuCAw</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Liu, Xiaoqian</creator><creator>Zhou, Zhong-Wei</creator><creator>Wang, Zhao-Qi</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20160701</creationdate><title>The DNA damage response molecule MCPH1 in brain development and beyond</title><author>Liu, Xiaoqian ; Zhou, Zhong-Wei ; Wang, Zhao-Qi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-6a709a2fccb5754847ba597660095ba81edfd8e0207bb813df9737910c0add2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Brain - embryology</topic><topic>Carcinogenesis</topic><topic>Chromosomal Proteins, Non-Histone - genetics</topic><topic>Chromosomal Proteins, Non-Histone - physiology</topic><topic>DNA Damage</topic><topic>DNA损伤</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>RNA, Messenger - genetics</topic><topic>分子</topic><topic>反应</topic><topic>大脑发育</topic><topic>神经前体细胞</topic><topic>细胞周期控制</topic><topic>细胞周期调控</topic><topic>肿瘤抑制基因</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiaoqian</creatorcontrib><creatorcontrib>Zhou, Zhong-Wei</creatorcontrib><creatorcontrib>Wang, Zhao-Qi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Acta biochimica et biophysica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiaoqian</au><au>Zhou, Zhong-Wei</au><au>Wang, Zhao-Qi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The DNA damage response molecule MCPH1 in brain development and beyond</atitle><jtitle>Acta biochimica et biophysica Sinica</jtitle><addtitle>Acta Biochimica et Biophysica Sinica</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>48</volume><issue>7</issue><spage>678</spage><epage>685</epage><pages>678-685</pages><issn>1672-9145</issn><eissn>1745-7270</eissn><abstract>Microcephalin （MCPH1） is identified as being responsible for the neurodevelopmental disorder pri- mary microcephaly type 1, which is characterized by a smaller-than-normal brain size and mental retardation. MCPH1 has originally been identified as an important regulator of telomere integrity and of cell cycle control. Genetic and cellular studies show that MCPH1 controls neurogenesis by coordinating the cell cycle and the centrosome cycle and thereby regulating the division mode of neuroprogenitors to prevent the exhaustion of the progenitor pool and thereby microcephaly. In addition to its role in neurogenesis, MCPH1 plays a role in gonad development. MCPH1 also func- tions as a tumor suppressor in several human cancers as well as in mouse models. Here, we review the role of MCPH1 in DNA damage response, cell cycle control, chromosome condensation and chromatin remodeling. We also summarize the studies on the biological functions of MCPH1 in brain size determination and in pathologies, including infertility and cancer.</abstract><cop>China</cop><pmid>27197793</pmid><doi>10.1093/abbs/gmw048</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Brain - embryology Carcinogenesis Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - physiology DNA Damage DNA损伤 Humans Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology RNA, Messenger - genetics 分子 反应 大脑发育 神经前体细胞 细胞周期控制 细胞周期调控 肿瘤抑制基因 |
| title | The DNA damage response molecule MCPH1 in brain development and beyond |
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