FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2

© 2015 Macmillan Publishers Limited. All rights reserved. T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is...

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Veröffentlicht in:	Oncogene 2016-08, Vol.35 (31), p.4141-4148
Hauptverfasser:	Fleskens, V., Mokry, D. M., van der Leun, A. M., Huppelschoten, S., Pals, C. E. G. M., Peeters, J., Coenen, S., Caetano Cardoso, Bruno António, Barata, João, van Loosdregt, J., Coffer, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	14 38 631/80/304 631/80/82 631/80/83 82/1 82/80 96/31 Acute lymphoblastic leukemia Adaptor Proteins, Signal Transducing - physiology Apoptosis Basic Helix-Loop-Helix Transcription Factors - genetics Carcinogenesis Cell Biology Cell Cycle Cell self-renewal Cell viability Cellular biology Forkhead protein Forkhead Transcription Factors - analysis Forkhead Transcription Factors - physiology Foxp3 protein Gene expression Genetic aspects Health aspects Human Genetics Humans Internal Medicine Leukemia LIM Domain Proteins - physiology Lymphatic leukemia Lymphocytes T Medicine Medicine & Public Health Oncology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Properties Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology short-communication T-Cell Acute Lymphocytic Leukemia Protein 1 Thymocytes Transcription factors Tumor suppressor genes Tumor Suppressor Proteins - physiology Tumors
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