Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer

•Administration of IL-24 increased the number of IFN-γ-producing CD8+T cell and especially enhanced the cytotoxicity of CD8+T cells.•The number and activity of CD8+T cells in TILs were increased, while the number of Treg cells in TILs was decreased greatly by IL-24.•The anti-tumor effect of IL-24 as...

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Veröffentlicht in:	Molecular immunology 2016-07, Vol.75, p.11-20
Hauptverfasser:	Ma, Yun-Feng, Ren, Yi, Wu, Cai-Jun, Zhao, Xiao-Hui, Xu, Hua, Wu, Da-Zhou, Xu, Jiru, Zhang, Xiao-Lian, Ji, Yanhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Colonic Neoplasms - immunology Cytokine Cytokines - immunology Cytokines - pharmacology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Humans Immunotherapy Interleukin-24 Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Male Mice Mice, Inbred BALB C Real-Time Polymerase Chain Reaction T cells Tumor microenvironment Tumor Microenvironment - immunology
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