Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration

Lipid nanocapsules (LNCs) are semi-rigid spherical capsules with a triglyceride core that present a promising formulation option for the pulmonary delivery of drugs with poor aqueous solubility. Whilst the biodistribution of LNCs of different size has been studied following intravenous administratio...

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Veröffentlicht in:	Journal of controlled release 2016-08, Vol.235, p.24-33
Hauptverfasser:	Patel, Aateka, Woods, A., Riffo-Vasquez, Yanira, Babin-Morgan, Anna, Jones, Marie-Christine, Jones, Stuart, Sunassee, Kavitha, Clark, Stephen, T. M. de Rosales, Rafael, Page, Clive, Spina, Domenico, Forbes, Ben, Dailey, Lea Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Biodistribution Bronchoalveolar Lavage Fluid - cytology Cell Count Half-Life Inflammation Kinetics Lipid nanocapsules Lipids - administration & dosage Lipids - pharmacokinetics Lipopolysaccharides Lung - drug effects Lung - metabolism Lung - pathology Lung clearance kinetics Male Mice, Inbred BALB C Nanocapsules - administration & dosage Pneumonia - chemically induced Pneumonia - metabolism Pneumonia - pathology Pulmonary drug delivery SPECT/CT Tissue Distribution
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