Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy

Conventional chemotherapy treatments for pancreatic cancer are mainly palliative. RNA interference (RNAi)-based drugs present the potential for a new targeted treatment. LOcal Drug EluteR (LODERTM) is a novel biodegradable polymeric matrix that shields drugs against enzymatic degradation and release...

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Veröffentlicht in:	Toxicologic pathology 2016-08, Vol.44 (6), p.856-865
Hauptverfasser:	Ramot, Yuval, Rotkopf, Shay, Gabai, Rachel Malka, Zorde Khvalevsky, Elina, Muravnik, Sofia, Marzoli, Gabriela Alejandra, Domb, Abraham J., Shemi, Amotz, Nyska, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Carcinoma, Pancreatic Ductal - drug therapy Drug Carriers - pharmacology Lactic Acid - pharmacology Pancreatic Neoplasms - drug therapy Polyglycolic Acid - pharmacology Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors Proto-Oncogene Proteins p21(ras) - genetics Rats Rats, Sprague-Dawley RNA, Small Interfering - pharmacology
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