Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis
Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a ri...
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| Veröffentlicht in: | Clinical rheumatology 2016-08, Vol.35 (8), p.2023-2029 |
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| container_title | Clinical rheumatology |
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| creator | Gentile, Marco Peluso, Rosario Di Minno, Matteo Nicola Dario Costa, Luisa Caso, Francesco de Simone, Biagio Iannuzzo, Gabriella Scarpa, Raffaele Rubba, Paolo |
| description | Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured. LDL particle separation was performed and seven LDL subfractions were obtained, LDL score (percentage of sd-LDL) and mean LDL particle size were calculated. PsA patients and control group differ significantly (
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| doi_str_mv | 10.1007/s10067-016-3344-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1811882546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811882546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-9110d3ace121f51689ccfd3f48cf4f26b1c3ee7fb11ecac2350b39c77868012d3</originalsourceid><addsrcrecordid>eNqNkU1r3DAQhkVpaTZJf0AvRdBLL240kmzJx5B-pLCQS3MWsjzuKnjlrUYm9N9Xy6alFAq9zBz0zCNmXsZeg3gPQpgrqrUzjYCuUUrrRj9jG9BKN32v--dsI4wRjYLenrFzogchhLQ9vGRn0mgAC-2GxWuiJURf4pL4gOURMXHa-3nmIyZCvv2w5T6NnNahCXNMMfiZ-7LDvFCYjzUSj4kfqgJTIf4Yy44faMlHaeA-l12OJdIlezH5mfDVU79g958-fr25bbZ3n7_cXG-boEVbmh5AjMoHBAlTC53tQ5hGNWkbJj3JboCgEM00AGDwQapWDKoPxtjOCpCjumDvTt5DXr6vSMXtIwWcZ59wWcnVvcFa2eruP1Bh6qmsVBV9-xf6sKw51UUqZTuprFJQKThRod6FMk7ukOPe5x8OhDtG5k6RuRqZO0bmdJ1582Rehz2Ovyd-ZVQBeQKoPqVvmP_4-p_Wn-zEoYk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886238331</pqid></control><display><type>article</type><title>Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Gentile, Marco ; Peluso, Rosario ; Di Minno, Matteo Nicola Dario ; Costa, Luisa ; Caso, Francesco ; de Simone, Biagio ; Iannuzzo, Gabriella ; Scarpa, Raffaele ; Rubba, Paolo</creator><creatorcontrib>Gentile, Marco ; Peluso, Rosario ; Di Minno, Matteo Nicola Dario ; Costa, Luisa ; Caso, Francesco ; de Simone, Biagio ; Iannuzzo, Gabriella ; Scarpa, Raffaele ; Rubba, Paolo</creatorcontrib><description>Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured. LDL particle separation was performed and seven LDL subfractions were obtained, LDL score (percentage of sd-LDL) and mean LDL particle size were calculated. PsA patients and control group differ significantly (
p
< 0.001) in triglycerides values (119.3 ± 52.0 vs 90.7 ± 40.7 mg/dL), Apo B (1.1 ± 0.2 vs 0.9 ± 0.1 g/L), insulin (8.9 ± 4.9 vs 5.8 ± 3.2 mU/L), HOMA (2.2 ± 1.7 vs 1.3 ± 0.8), BMI (27.7 ± 3.3 vs 25.8 ± 3.8). LDL score is significantly higher in PsA as compared to control (9.0 ± 10.7 vs 2.9 ± 4.7 mg/dL); and mean LDL size is significantly lower in PsA than control (268.1 ± 4.6 vs 271.2 ± 2.7 Å). These differences were confirmed when stratifying PsA patients for treatment and for disease activity. LDL score and LDL diameter significantly were correlated with the carotid IMT in patients with PsA. These findings show a novel relationship between LDL score and mean LDL size with PsA diagnosis and with sub-clinical atherosclerosis. Sd-LDL gives potentially useful information in the risk assessment for atherosclerotic disease in PsA patients.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3344-4</identifier><identifier>PMID: 27411815</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Apolipoproteins B - blood ; Arthritis, Psoriatic - blood ; Arthritis, Psoriatic - complications ; Atherosclerosis - blood ; Atherosclerosis - complications ; Carotid Intima-Media Thickness ; Case-Control Studies ; Cholesterol, LDL - blood ; Female ; Humans ; Insulin - blood ; Italy ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Rheumatology ; Risk Factors ; Triglycerides - blood</subject><ispartof>Clinical rheumatology, 2016-08, Vol.35 (8), p.2023-2029</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><rights>Clinical Rheumatology is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9110d3ace121f51689ccfd3f48cf4f26b1c3ee7fb11ecac2350b39c77868012d3</citedby><cites>FETCH-LOGICAL-c405t-9110d3ace121f51689ccfd3f48cf4f26b1c3ee7fb11ecac2350b39c77868012d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-016-3344-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-016-3344-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27411815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gentile, Marco</creatorcontrib><creatorcontrib>Peluso, Rosario</creatorcontrib><creatorcontrib>Di Minno, Matteo Nicola Dario</creatorcontrib><creatorcontrib>Costa, Luisa</creatorcontrib><creatorcontrib>Caso, Francesco</creatorcontrib><creatorcontrib>de Simone, Biagio</creatorcontrib><creatorcontrib>Iannuzzo, Gabriella</creatorcontrib><creatorcontrib>Scarpa, Raffaele</creatorcontrib><creatorcontrib>Rubba, Paolo</creatorcontrib><title>Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured. LDL particle separation was performed and seven LDL subfractions were obtained, LDL score (percentage of sd-LDL) and mean LDL particle size were calculated. PsA patients and control group differ significantly (
p
< 0.001) in triglycerides values (119.3 ± 52.0 vs 90.7 ± 40.7 mg/dL), Apo B (1.1 ± 0.2 vs 0.9 ± 0.1 g/L), insulin (8.9 ± 4.9 vs 5.8 ± 3.2 mU/L), HOMA (2.2 ± 1.7 vs 1.3 ± 0.8), BMI (27.7 ± 3.3 vs 25.8 ± 3.8). LDL score is significantly higher in PsA as compared to control (9.0 ± 10.7 vs 2.9 ± 4.7 mg/dL); and mean LDL size is significantly lower in PsA than control (268.1 ± 4.6 vs 271.2 ± 2.7 Å). These differences were confirmed when stratifying PsA patients for treatment and for disease activity. LDL score and LDL diameter significantly were correlated with the carotid IMT in patients with PsA. These findings show a novel relationship between LDL score and mean LDL size with PsA diagnosis and with sub-clinical atherosclerosis. Sd-LDL gives potentially useful information in the risk assessment for atherosclerotic disease in PsA patients.</description><subject>Apolipoproteins B - blood</subject><subject>Arthritis, Psoriatic - blood</subject><subject>Arthritis, Psoriatic - complications</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - complications</subject><subject>Carotid Intima-Media Thickness</subject><subject>Case-Control Studies</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Italy</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1r3DAQhkVpaTZJf0AvRdBLL240kmzJx5B-pLCQS3MWsjzuKnjlrUYm9N9Xy6alFAq9zBz0zCNmXsZeg3gPQpgrqrUzjYCuUUrrRj9jG9BKN32v--dsI4wRjYLenrFzogchhLQ9vGRn0mgAC-2GxWuiJURf4pL4gOURMXHa-3nmIyZCvv2w5T6NnNahCXNMMfiZ-7LDvFCYjzUSj4kfqgJTIf4Yy44faMlHaeA-l12OJdIlezH5mfDVU79g958-fr25bbZ3n7_cXG-boEVbmh5AjMoHBAlTC53tQ5hGNWkbJj3JboCgEM00AGDwQapWDKoPxtjOCpCjumDvTt5DXr6vSMXtIwWcZ59wWcnVvcFa2eruP1Bh6qmsVBV9-xf6sKw51UUqZTuprFJQKThRod6FMk7ukOPe5x8OhDtG5k6RuRqZO0bmdJ1582Rehz2Ovyd-ZVQBeQKoPqVvmP_4-p_Wn-zEoYk</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Gentile, Marco</creator><creator>Peluso, Rosario</creator><creator>Di Minno, Matteo Nicola Dario</creator><creator>Costa, Luisa</creator><creator>Caso, Francesco</creator><creator>de Simone, Biagio</creator><creator>Iannuzzo, Gabriella</creator><creator>Scarpa, Raffaele</creator><creator>Rubba, Paolo</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis</title><author>Gentile, Marco ; Peluso, Rosario ; Di Minno, Matteo Nicola Dario ; Costa, Luisa ; Caso, Francesco ; de Simone, Biagio ; Iannuzzo, Gabriella ; Scarpa, Raffaele ; Rubba, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9110d3ace121f51689ccfd3f48cf4f26b1c3ee7fb11ecac2350b39c77868012d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Apolipoproteins B - blood</topic><topic>Arthritis, Psoriatic - blood</topic><topic>Arthritis, Psoriatic - complications</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - complications</topic><topic>Carotid Intima-Media Thickness</topic><topic>Case-Control Studies</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Italy</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gentile, Marco</creatorcontrib><creatorcontrib>Peluso, Rosario</creatorcontrib><creatorcontrib>Di Minno, Matteo Nicola Dario</creatorcontrib><creatorcontrib>Costa, Luisa</creatorcontrib><creatorcontrib>Caso, Francesco</creatorcontrib><creatorcontrib>de Simone, Biagio</creatorcontrib><creatorcontrib>Iannuzzo, Gabriella</creatorcontrib><creatorcontrib>Scarpa, Raffaele</creatorcontrib><creatorcontrib>Rubba, Paolo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gentile, Marco</au><au>Peluso, Rosario</au><au>Di Minno, Matteo Nicola Dario</au><au>Costa, Luisa</au><au>Caso, Francesco</au><au>de Simone, Biagio</au><au>Iannuzzo, Gabriella</au><au>Scarpa, Raffaele</au><au>Rubba, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>35</volume><issue>8</issue><spage>2023</spage><epage>2029</epage><pages>2023-2029</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured. LDL particle separation was performed and seven LDL subfractions were obtained, LDL score (percentage of sd-LDL) and mean LDL particle size were calculated. PsA patients and control group differ significantly (
p
< 0.001) in triglycerides values (119.3 ± 52.0 vs 90.7 ± 40.7 mg/dL), Apo B (1.1 ± 0.2 vs 0.9 ± 0.1 g/L), insulin (8.9 ± 4.9 vs 5.8 ± 3.2 mU/L), HOMA (2.2 ± 1.7 vs 1.3 ± 0.8), BMI (27.7 ± 3.3 vs 25.8 ± 3.8). LDL score is significantly higher in PsA as compared to control (9.0 ± 10.7 vs 2.9 ± 4.7 mg/dL); and mean LDL size is significantly lower in PsA than control (268.1 ± 4.6 vs 271.2 ± 2.7 Å). These differences were confirmed when stratifying PsA patients for treatment and for disease activity. LDL score and LDL diameter significantly were correlated with the carotid IMT in patients with PsA. These findings show a novel relationship between LDL score and mean LDL size with PsA diagnosis and with sub-clinical atherosclerosis. Sd-LDL gives potentially useful information in the risk assessment for atherosclerotic disease in PsA patients.</abstract><cop>London</cop><pub>Springer London</pub><pmid>27411815</pmid><doi>10.1007/s10067-016-3344-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Apolipoproteins B - blood Arthritis, Psoriatic - blood Arthritis, Psoriatic - complications Atherosclerosis - blood Atherosclerosis - complications Carotid Intima-Media Thickness Case-Control Studies Cholesterol, LDL - blood Female Humans Insulin - blood Italy Logistic Models Male Medicine Medicine & Public Health Middle Aged Original Article Rheumatology Risk Factors Triglycerides - blood |
| title | Association between small dense LDL and sub-clinical atherosclerosis in patients with psoriatic arthritis |
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