Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients
We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was co...
Gespeichert in:
| Veröffentlicht in: | Heart and vessels 2016-08, Vol.31 (8), p.1218-1229 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1229 |
|---|---|
| container_issue | 8 |
| container_start_page | 1218 |
| container_title | Heart and vessels |
| container_volume | 31 |
| creator | Afrasyab, Altaf Qu, Peng Zhao, Yang Peng, Kuang Wang, Hongyan Lou, Dayuan Niu, Nan Yuan, Dajun |
| description | We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was correlated with clinical presentation, angiographic characteristics and its scoring systems as well as GRACE and TIMI risk scores. Follow-up for major adverse cardiac events (MACE) was carried out at 180 days. Peripheral blood monocyte NLRP3 was found to be elevated in ACS patients (
P
|
| doi_str_mv | 10.1007/s00380-015-0723-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1811881713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811881713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-e7503a4a136fb9dbd57d2ecf2654e6e438d8176a22aa84ab90c30aca4f188c1c3</originalsourceid><addsrcrecordid>eNqNkUFv1DAQha0K1C4tP4ALisSFS9oZO4mdI1qVUmlFEaJny-tM2lRZe7ETUP99Z7ulICQkLras982b8Twh3iCcIoA-ywDKQAlYl6ClKs2BWGDDL1lr9UIsoEUojZL6SLzK-Q4YbLE9FEeykS1g0yzEdhlTotFNQwxF7IvPq69fVPFzmG6LTD8oDdN94UJXbFO8CTEPeQf5mGJwiZXpllLMftydrA2hcH6e6DeR70OX4oaKLbegMOUT8bJ3Y6bXT_exuP54_m35qVxdXVwuP6xKX8l2KknXoFzlUDX9uu3WXa07Sb6XTV1RQ5UynUHdOCmdM5Vbt-AVOO-qHo3x6NWxeL_35cm_z5Qnuxmyp3F0geKcLRpkEjWq_0DBKMY1MPruL_QuzinwRx4NQVVaaaZwT3leS07U220aNrwOi2B3ydl9cpYDsbvkrOGat0_O83pD3XPFr6gYkHsgsxRuKP3R-p-uD4TkpHI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1811034737</pqid></control><display><type>article</type><title>Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Afrasyab, Altaf ; Qu, Peng ; Zhao, Yang ; Peng, Kuang ; Wang, Hongyan ; Lou, Dayuan ; Niu, Nan ; Yuan, Dajun</creator><creatorcontrib>Afrasyab, Altaf ; Qu, Peng ; Zhao, Yang ; Peng, Kuang ; Wang, Hongyan ; Lou, Dayuan ; Niu, Nan ; Yuan, Dajun</creatorcontrib><description>We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was correlated with clinical presentation, angiographic characteristics and its scoring systems as well as GRACE and TIMI risk scores. Follow-up for major adverse cardiac events (MACE) was carried out at 180 days. Peripheral blood monocyte NLRP3 was found to be elevated in ACS patients (
P
< 0.05) and showed positive correlation with GRACE score (
r
= 0.619), TIMI score (
r
= 0.580), SYNTAX score (
r
= 0.550), Clinical SYNTAX score (
r
= 0.564) and Gensini score (
r
= 0.516). NLRP3 was also increased with increasing number of vessels, the number of lesions present and the presence bifurcation lesions (
P
< 0.05). Multivariate Cox regression analysis showed NLRP3 to be an independent predictor of MACE (
P
= 0.043). Kaplan–Meier analysis and receiver operating characteristic curves for NLRP3 showed good predictive value for MACE. There is a positive correlation of NLRP3 level with severity of coronary atherosclerosis. NLRP3 level is a promising prognostic utility and is efficient in event prediction for MACE.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-015-0723-8</identifier><identifier>PMID: 26290166</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acute Coronary Syndrome - complications ; Acute Coronary Syndrome - mortality ; Acute coronary syndromes ; Aged ; Atherosclerosis ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Cardiology ; Case-Control Studies ; Coronary Angiography ; Coronary Artery Disease - blood ; Creatinine - blood ; Female ; Humans ; Kaplan-Meier Estimate ; Lipids - blood ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; NLR Family, Pyrin Domain-Containing 3 Protein - blood ; Original Article ; Prognosis ; Proportional Hazards Models ; Protein expression ; Risk Assessment ; Risk Factors ; ROC Curve ; Severity of Illness Index ; Vascular Surgery</subject><ispartof>Heart and vessels, 2016-08, Vol.31 (8), p.1218-1229</ispartof><rights>Springer Japan 2015</rights><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-e7503a4a136fb9dbd57d2ecf2654e6e438d8176a22aa84ab90c30aca4f188c1c3</citedby><cites>FETCH-LOGICAL-c429t-e7503a4a136fb9dbd57d2ecf2654e6e438d8176a22aa84ab90c30aca4f188c1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-015-0723-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-015-0723-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26290166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Afrasyab, Altaf</creatorcontrib><creatorcontrib>Qu, Peng</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Peng, Kuang</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><creatorcontrib>Lou, Dayuan</creatorcontrib><creatorcontrib>Niu, Nan</creatorcontrib><creatorcontrib>Yuan, Dajun</creatorcontrib><title>Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was correlated with clinical presentation, angiographic characteristics and its scoring systems as well as GRACE and TIMI risk scores. Follow-up for major adverse cardiac events (MACE) was carried out at 180 days. Peripheral blood monocyte NLRP3 was found to be elevated in ACS patients (
P
< 0.05) and showed positive correlation with GRACE score (
r
= 0.619), TIMI score (
r
= 0.580), SYNTAX score (
r
= 0.550), Clinical SYNTAX score (
r
= 0.564) and Gensini score (
r
= 0.516). NLRP3 was also increased with increasing number of vessels, the number of lesions present and the presence bifurcation lesions (
P
< 0.05). Multivariate Cox regression analysis showed NLRP3 to be an independent predictor of MACE (
P
= 0.043). Kaplan–Meier analysis and receiver operating characteristic curves for NLRP3 showed good predictive value for MACE. There is a positive correlation of NLRP3 level with severity of coronary atherosclerosis. NLRP3 level is a promising prognostic utility and is efficient in event prediction for MACE.</description><subject>Acute Coronary Syndrome - complications</subject><subject>Acute Coronary Syndrome - mortality</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - blood</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - blood</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Protein expression</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUFv1DAQha0K1C4tP4ALisSFS9oZO4mdI1qVUmlFEaJny-tM2lRZe7ETUP99Z7ulICQkLras982b8Twh3iCcIoA-ywDKQAlYl6ClKs2BWGDDL1lr9UIsoEUojZL6SLzK-Q4YbLE9FEeykS1g0yzEdhlTotFNQwxF7IvPq69fVPFzmG6LTD8oDdN94UJXbFO8CTEPeQf5mGJwiZXpllLMftydrA2hcH6e6DeR70OX4oaKLbegMOUT8bJ3Y6bXT_exuP54_m35qVxdXVwuP6xKX8l2KknXoFzlUDX9uu3WXa07Sb6XTV1RQ5UynUHdOCmdM5Vbt-AVOO-qHo3x6NWxeL_35cm_z5Qnuxmyp3F0geKcLRpkEjWq_0DBKMY1MPruL_QuzinwRx4NQVVaaaZwT3leS07U220aNrwOi2B3ydl9cpYDsbvkrOGat0_O83pD3XPFr6gYkHsgsxRuKP3R-p-uD4TkpHI</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Afrasyab, Altaf</creator><creator>Qu, Peng</creator><creator>Zhao, Yang</creator><creator>Peng, Kuang</creator><creator>Wang, Hongyan</creator><creator>Lou, Dayuan</creator><creator>Niu, Nan</creator><creator>Yuan, Dajun</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients</title><author>Afrasyab, Altaf ; Qu, Peng ; Zhao, Yang ; Peng, Kuang ; Wang, Hongyan ; Lou, Dayuan ; Niu, Nan ; Yuan, Dajun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-e7503a4a136fb9dbd57d2ecf2654e6e438d8176a22aa84ab90c30aca4f188c1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute Coronary Syndrome - complications</topic><topic>Acute Coronary Syndrome - mortality</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - blood</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - blood</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Protein expression</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Afrasyab, Altaf</creatorcontrib><creatorcontrib>Qu, Peng</creatorcontrib><creatorcontrib>Zhao, Yang</creatorcontrib><creatorcontrib>Peng, Kuang</creatorcontrib><creatorcontrib>Wang, Hongyan</creatorcontrib><creatorcontrib>Lou, Dayuan</creatorcontrib><creatorcontrib>Niu, Nan</creatorcontrib><creatorcontrib>Yuan, Dajun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Afrasyab, Altaf</au><au>Qu, Peng</au><au>Zhao, Yang</au><au>Peng, Kuang</au><au>Wang, Hongyan</au><au>Lou, Dayuan</au><au>Niu, Nan</au><au>Yuan, Dajun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>31</volume><issue>8</issue><spage>1218</spage><epage>1229</epage><pages>1218-1229</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>We decided to assess the prognostic value of NLRP3 inflammasome level in acute coronary syndrome (ACS) patients and whether it was related to coronary atherosclerotic severity. Study population included one-hundred and twenty-three (123) subjects. Peripheral blood monocyte NLRP3 protein level was correlated with clinical presentation, angiographic characteristics and its scoring systems as well as GRACE and TIMI risk scores. Follow-up for major adverse cardiac events (MACE) was carried out at 180 days. Peripheral blood monocyte NLRP3 was found to be elevated in ACS patients (
P
< 0.05) and showed positive correlation with GRACE score (
r
= 0.619), TIMI score (
r
= 0.580), SYNTAX score (
r
= 0.550), Clinical SYNTAX score (
r
= 0.564) and Gensini score (
r
= 0.516). NLRP3 was also increased with increasing number of vessels, the number of lesions present and the presence bifurcation lesions (
P
< 0.05). Multivariate Cox regression analysis showed NLRP3 to be an independent predictor of MACE (
P
= 0.043). Kaplan–Meier analysis and receiver operating characteristic curves for NLRP3 showed good predictive value for MACE. There is a positive correlation of NLRP3 level with severity of coronary atherosclerosis. NLRP3 level is a promising prognostic utility and is efficient in event prediction for MACE.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26290166</pmid><doi>10.1007/s00380-015-0723-8</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-8327 |
| ispartof | Heart and vessels, 2016-08, Vol.31 (8), p.1218-1229 |
| issn | 0910-8327 1615-2573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1811881713 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Coronary Syndrome - complications Acute Coronary Syndrome - mortality Acute coronary syndromes Aged Atherosclerosis Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Case-Control Studies Coronary Angiography Coronary Artery Disease - blood Creatinine - blood Female Humans Kaplan-Meier Estimate Lipids - blood Male Medical prognosis Medicine Medicine & Public Health Middle Aged Multivariate Analysis NLR Family, Pyrin Domain-Containing 3 Protein - blood Original Article Prognosis Proportional Hazards Models Protein expression Risk Assessment Risk Factors ROC Curve Severity of Illness Index Vascular Surgery |
| title | Correlation of NLRP3 with severity and prognosis of coronary atherosclerosis in acute coronary syndrome patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A17%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20NLRP3%20with%20severity%20and%20prognosis%20of%20coronary%20atherosclerosis%20in%20acute%20coronary%20syndrome%20patients&rft.jtitle=Heart%20and%20vessels&rft.au=Afrasyab,%20Altaf&rft.date=2016-08-01&rft.volume=31&rft.issue=8&rft.spage=1218&rft.epage=1229&rft.pages=1218-1229&rft.issn=0910-8327&rft.eissn=1615-2573&rft.coden=HEVEEO&rft_id=info:doi/10.1007/s00380-015-0723-8&rft_dat=%3Cproquest_cross%3E1811881713%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1811034737&rft_id=info:pmid/26290166&rfr_iscdi=true |