Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects
ABSTRACT Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The pre...
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| Veröffentlicht in: | Developmental psychobiology 2016-09, Vol.58 (6), p.670-686 |
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| container_title | Developmental psychobiology |
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| creator | Macchione, A. F. Anunziata, F. Culleré, M. E. Haymal, B. O. Spear, N. Abate, P. Molina, J. C. |
| description | ABSTRACT
Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670–686, 2016. |
| doi_str_mv | 10.1002/dev.21398 |
| format | Article |
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Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670–686, 2016.</description><identifier>ISSN: 0012-1630</identifier><identifier>EISSN: 1098-2302</identifier><identifier>DOI: 10.1002/dev.21398</identifier><identifier>PMID: 27255447</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Alcoholic Intoxication - physiopathology ; Animals ; Animals, Newborn ; breathing depressions ; Central Nervous System Depressants - administration & dosage ; Central Nervous System Depressants - pharmacology ; conditioning ; Conditioning, Classical - physiology ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Female ; Male ; neonate ethanol intoxication ; Rats ; Rats, Wistar ; Respiration - drug effects ; sensitization ; Smell - physiology</subject><ispartof>Developmental psychobiology, 2016-09, Vol.58 (6), p.670-686</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6418-698a3397c0e5b18ef157cbb970251606b63c17f6a71d3c018471dfcf3244b8693</citedby><cites>FETCH-LOGICAL-c6418-698a3397c0e5b18ef157cbb970251606b63c17f6a71d3c018471dfcf3244b8693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdev.21398$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdev.21398$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27255447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macchione, A. F.</creatorcontrib><creatorcontrib>Anunziata, F.</creatorcontrib><creatorcontrib>Culleré, M. E.</creatorcontrib><creatorcontrib>Haymal, B. O.</creatorcontrib><creatorcontrib>Spear, N.</creatorcontrib><creatorcontrib>Abate, P.</creatorcontrib><creatorcontrib>Molina, J. C.</creatorcontrib><title>Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects</title><title>Developmental psychobiology</title><addtitle>Dev Psychobiol</addtitle><description>ABSTRACT
Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670–686, 2016.</description><subject>Alcoholic Intoxication - physiopathology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>breathing depressions</subject><subject>Central Nervous System Depressants - administration & dosage</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>conditioning</subject><subject>Conditioning, Classical - physiology</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Male</subject><subject>neonate ethanol intoxication</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Respiration - drug effects</subject><subject>sensitization</subject><subject>Smell - physiology</subject><issn>0012-1630</issn><issn>1098-2302</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvFDEQhC0EIkvgwB9AvgGHSdz2jO05wuYBIgIOvG6Wx4-sYXa82B6SnPnjeNlNbkicurv0VUmtQugpkCMghB5b9-uIAuvlPbQA0suGMkLvowUhQBvgjBygRzl_rye0UjxEB1TQrmtbsUC_l3GyoYQ4OYuH5HRZhekSW7dJLucqYzunrTK5OOmiRzwG77DOWGM_T2brxNFXIUcTdNmirqz0FEccbUxYTxaXlcM2zZfPMw5TidfB7EHvnSn5MXrg9Zjdk_08RJ_PTj8t3zQXH87fLl9dNIa3IBveS81YLwxx3QDSeeiEGYZeENoBJ3zgzIDwXAuwzBCQbV288Yy27SB5zw7Ri13uJsWfs8tFrUM2bhx1fW7OCiSAlMB7-h8o6TkBDm1FX-5Qk2LOyXm1SWGt040Corb1qFqP-ltPZZ_tY-dh7ewdedtHBY53wFUY3c2_k9TJ6ZfbyGbnCLm46zuHTj8UF0x06uv7c_WO9h9P2tffFGF_ANYOqU8</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Macchione, A. F.</creator><creator>Anunziata, F.</creator><creator>Culleré, M. E.</creator><creator>Haymal, B. O.</creator><creator>Spear, N.</creator><creator>Abate, P.</creator><creator>Molina, J. C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201609</creationdate><title>Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects</title><author>Macchione, A. F. ; Anunziata, F. ; Culleré, M. E. ; Haymal, B. O. ; Spear, N. ; Abate, P. ; Molina, J. 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F.</creatorcontrib><creatorcontrib>Anunziata, F.</creatorcontrib><creatorcontrib>Culleré, M. E.</creatorcontrib><creatorcontrib>Haymal, B. O.</creatorcontrib><creatorcontrib>Spear, N.</creatorcontrib><creatorcontrib>Abate, P.</creatorcontrib><creatorcontrib>Molina, J. C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Developmental psychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macchione, A. F.</au><au>Anunziata, F.</au><au>Culleré, M. E.</au><au>Haymal, B. O.</au><au>Spear, N.</au><au>Abate, P.</au><au>Molina, J. 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Fetal and neonatal ethanol‐related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670–686, 2016.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27255447</pmid><doi>10.1002/dev.21398</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alcoholic Intoxication - physiopathology Animals Animals, Newborn breathing depressions Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology conditioning Conditioning, Classical - physiology Ethanol - administration & dosage Ethanol - pharmacology Female Male neonate ethanol intoxication Rats Rats, Wistar Respiration - drug effects sensitization Smell - physiology |
| title | Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects |
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