LFG-500, a newly synthesized flavonoid, attenuates lipopolysaccharide-induced acute lung injury and inflammation in mice

[Display omitted] Acute lung injury (ALI) often causes significant morbidity and mortality worldwide. Improved treatment and effective strategies are still required for ALI patients. Our previous studies demonstrated that LFG-500, a novel synthesized flavonoid, has potent anti-cancer activities, whi...

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Veröffentlicht in:	Biochemical pharmacology 2016-08, Vol.113, p.57-69
Hauptverfasser:	Li, Chenglin, Yang, Dan, Cao, Xin, Wang, Fan, Jiang, Haijing, Guo, Hao, Du, Lei, Guo, Qinglong, Yin, Xiaoxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury Acute Lung Injury - chemically induced Acute Lung Injury - immunology Acute Lung Injury - pathology Acute Lung Injury - prevention & control Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - therapeutic use Cell Line, Tumor Cytokines - secretion Disease Models, Animal Female Flavonoids - administration & dosage Flavonoids - chemical synthesis Flavonoids - therapeutic use Humans LFG-500 Lipopolysaccharide Lipopolysaccharides - toxicity Macrophages - drug effects Macrophages - secretion Mice, Inbred C57BL Molecular Structure NF-κB
Online-Zugang:	Volltext
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