Curcumin Attenuated Bupivacaine-Induced Neurotoxicity in SH-SY5Y Cells Via Activation of the Akt Signaling Pathway

Bupivacaine is widely used for regional anesthesia, spinal anesthesia, and pain management. However, bupivacaine could cause neuronal injury. Curcumin, a low molecular weight polyphenol, has a variety of bioactivities and may exert neuroprotective effects against damage induced by some stimuli. In t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurochemical research 2016-09, Vol.41 (9), p.2425-2432
Hauptverfasser:	Fan, You-Ling, Li, Heng-Chang, Zhao, Wei, Peng, Hui-Hua, Huang, Fang, Jiang, Wei-Hang, Xu, Shi-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein Anesthesia Apoptosis Apoptosis - drug effects Attenuation Biochemistry Biomedical and Life Sciences Biomedicine Bupivacaine Bupivacaine - pharmacology Cell Biology Cell injury Cell Line, Tumor Cell Survival - drug effects Curcumin Curcumin - pharmacology Damage assessment Humans Inhibition Injuries Kinases Local anesthesia Low molecular weights Membrane Potential, Mitochondrial - drug effects Mitochondria Molecular weight Neurochemistry Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Neurotoxicity Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - metabolism Original Paper Pain Pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signal Transduction - drug effects Signaling
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!