Change in Neutrophil-to-lymphocyte Ratio in Response to Targeted Therapy for Metastatic Renal Cell Carcinoma as a Prognosticator and Biomarker of Efficacy

Abstract Background Neutrophil-to-lymphocyte ratio (NLR), if elevated, is associated with worse outcomes in several malignancies. Objective Investigation of NLR at baseline and during therapy for metastatic renal cell carcinoma. Design, setting, and participants Retrospective analysis of 1199 patien...

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Veröffentlicht in:	European urology 2016-08, Vol.70 (2), p.358-364
Hauptverfasser:	Templeton, Arnoud J, Knox, Jennifer J, Lin, Xun, Simantov, Ronit, Xie, Wanling, Lawrence, Nicola, Broom, Reuben, Fay, André P, Rini, Brian, Donskov, Frede, Bjarnason, Georg A, Smoragiewicz, Martin, Kollmannsberger, Christian, Kanesvaran, Ravindran, Alimohamed, Nimira, Hermanns, Thomas, Wells, J. Connor, Amir, Eitan, Choueiri, Toni K, Heng, Daniel Y.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - pathology Change Conversion Drug Monitoring - methods Female Humans Leukocyte Count - methods Lymphocytes - pathology Male Middle Aged Molecular Targeted Therapy - methods Neoplasm Metastasis Neoplasm Staging Neutrophil-to-lymphocyte ratio Neutrophils - pathology Outcome Assessment (Health Care) Predictive Value of Tests Prognosis Proportional Hazards Models Renal cell carcinoma Targeted therapy Urology
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