The Relationship of BMD Increases Between the First 12 Months and the Latter 12 Months by Daily Teriparatide Treatment
The degree of correlation between the first 12 months and the latter 12 months of increased bone mineral density (BMD) with teriparatide treatment is unknown. We retrospectively investigated the correlation between the first 12 months and the latter 12 months of increased BMD owing to teriparatide t...
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| Veröffentlicht in: | Calcified tissue international 2016-09, Vol.99 (3), p.282-288 |
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| creator | Niimi, Rui Kono, Toshibumi Nishihara, Atsushi Hasegawa, Masahiro Kono, Toshihiko Sudo, Akihiro |
| description | The degree of correlation between the first 12 months and the latter 12 months of increased bone mineral density (BMD) with teriparatide treatment is unknown. We retrospectively investigated the correlation between the first 12 months and the latter 12 months of increased BMD owing to teriparatide treatment. We retrospectively analyzed 357 patients (mean age, 78 years) with osteoporosis treated with teriparatide 20 μg/day for 24 months. The primary efficacy measure was the correlation between lumbar spine (LS) and femoral neck (FN) BMD increases from baseline to 12 months and from 12 to 24 months. The correlation between the first 12 months and the latter 12 months of increased BMD was evaluated. We investigated the correlation between the increases in BMD and the baseline procollagen type I N-terminal propeptide (PINP) concentration. LS BMD significantly increased by 9.7 ± 8.3 % in the first 12 months and 3.5 ± 4.8 % in the latter 12 months. FN BMD increased by 2.2 ± 8.4 % in the first 12 months and 1.3 ± 4.9 % in the latter 12 months. Increased LS and FN BMD were not significantly correlated between the first 12 months and the latter 12 months. The serum baseline PINP concentration was correlated with the LS BMD in the first 12 months, and similarly, the PINP concentration at 12 months was correlated with the latter 12 months of increased LS BMD. Increased BMD by teriparatide treatment in the first 12 months and the latter 12 months was not significantly correlated. |
| doi_str_mv | 10.1007/s00223-016-0151-5 |
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We retrospectively investigated the correlation between the first 12 months and the latter 12 months of increased BMD owing to teriparatide treatment. We retrospectively analyzed 357 patients (mean age, 78 years) with osteoporosis treated with teriparatide 20 μg/day for 24 months. The primary efficacy measure was the correlation between lumbar spine (LS) and femoral neck (FN) BMD increases from baseline to 12 months and from 12 to 24 months. The correlation between the first 12 months and the latter 12 months of increased BMD was evaluated. We investigated the correlation between the increases in BMD and the baseline procollagen type I N-terminal propeptide (PINP) concentration. LS BMD significantly increased by 9.7 ± 8.3 % in the first 12 months and 3.5 ± 4.8 % in the latter 12 months. FN BMD increased by 2.2 ± 8.4 % in the first 12 months and 1.3 ± 4.9 % in the latter 12 months. Increased LS and FN BMD were not significantly correlated between the first 12 months and the latter 12 months. The serum baseline PINP concentration was correlated with the LS BMD in the first 12 months, and similarly, the PINP concentration at 12 months was correlated with the latter 12 months of increased LS BMD. Increased BMD by teriparatide treatment in the first 12 months and the latter 12 months was not significantly correlated.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-016-0151-5</identifier><identifier>PMID: 27206528</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biochemistry ; Biomedical and Life Sciences ; Bone density ; Bone Density - drug effects ; Bone Density Conservation Agents - administration & dosage ; Bone Density Conservation Agents - therapeutic use ; Bone Remodeling - drug effects ; Bones ; Cell Biology ; Clinical trials ; Drug Administration Schedule ; Endocrinology ; Female ; Fractures ; Humans ; Life Sciences ; Lumbar Vertebrae - drug effects ; Lumbar Vertebrae - physiopathology ; Male ; Middle Aged ; Original Research ; Orthopedics ; Osteoporosis ; Osteoporosis - diagnosis ; Osteoporosis - drug therapy ; Retrospective Studies ; Teriparatide - administration & dosage ; Teriparatide - therapeutic use ; Time Factors ; Treatment Outcome</subject><ispartof>Calcified tissue international, 2016-09, Vol.99 (3), p.282-288</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Calcified Tissue International is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-94a3d40a9d1681b8d328779d8cf1cbd73aab22331c51b938b15b568cb650d58d3</citedby><cites>FETCH-LOGICAL-c471t-94a3d40a9d1681b8d328779d8cf1cbd73aab22331c51b938b15b568cb650d58d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-016-0151-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-016-0151-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27206528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niimi, Rui</creatorcontrib><creatorcontrib>Kono, Toshibumi</creatorcontrib><creatorcontrib>Nishihara, Atsushi</creatorcontrib><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Kono, Toshihiko</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><title>The Relationship of BMD Increases Between the First 12 Months and the Latter 12 Months by Daily Teriparatide Treatment</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>The degree of correlation between the first 12 months and the latter 12 months of increased bone mineral density (BMD) with teriparatide treatment is unknown. We retrospectively investigated the correlation between the first 12 months and the latter 12 months of increased BMD owing to teriparatide treatment. We retrospectively analyzed 357 patients (mean age, 78 years) with osteoporosis treated with teriparatide 20 μg/day for 24 months. The primary efficacy measure was the correlation between lumbar spine (LS) and femoral neck (FN) BMD increases from baseline to 12 months and from 12 to 24 months. The correlation between the first 12 months and the latter 12 months of increased BMD was evaluated. We investigated the correlation between the increases in BMD and the baseline procollagen type I N-terminal propeptide (PINP) concentration. LS BMD significantly increased by 9.7 ± 8.3 % in the first 12 months and 3.5 ± 4.8 % in the latter 12 months. FN BMD increased by 2.2 ± 8.4 % in the first 12 months and 1.3 ± 4.9 % in the latter 12 months. Increased LS and FN BMD were not significantly correlated between the first 12 months and the latter 12 months. The serum baseline PINP concentration was correlated with the LS BMD in the first 12 months, and similarly, the PINP concentration at 12 months was correlated with the latter 12 months of increased LS BMD. Increased BMD by teriparatide treatment in the first 12 months and the latter 12 months was not significantly correlated.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone Density Conservation Agents - therapeutic use</subject><subject>Bone Remodeling - drug effects</subject><subject>Bones</subject><subject>Cell Biology</subject><subject>Clinical trials</subject><subject>Drug Administration Schedule</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fractures</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lumbar Vertebrae - drug effects</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Osteoporosis - diagnosis</subject><subject>Osteoporosis - drug therapy</subject><subject>Retrospective Studies</subject><subject>Teriparatide - administration & dosage</subject><subject>Teriparatide - therapeutic use</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc9qVDEUh4NY7Fh9ADcScOPm2pzk5s9d2tZqYYogI7gLyc0Z55Y7uWOSQedt-ix9MlOnllIQXIQsft_5HZKPkFfA3gFj-jgzxrloGKh6JDTyCZlBK3jDDNdPyYyBhqZT-tsheZ7zFWPQKqWekUOuOVOSmxn5tVgh_YKjK8MU82rY0GlJTy7P6EXsE7qMmZ5g-YkYaank-ZByocBvri-nWFaZuhj-BHNXCqaHid_RMzeMO7rANGxcqhsC0kUtLWuM5QU5WLox48u7-4h8Pf-wOP3UzD9_vDh9P2_6VkNputaJ0DLXBVAGvAmCG627YPol9D5o4ZyvfyCgl-A7YTxIL5XpvZIsyIofkbf73k2afmwxF7seco_j6CJO22zBANRG0Yn_QJnmumsVVPTNI_Rq2qZYH1Ipo7gwouWVgj3VpynnhEu7ScPapZ0FZm8N2r1BWw3aW4NW1pnXd81bv8ZwP_FXWQX4Hsg1it8xPVj9z9bfqu6lag</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Niimi, Rui</creator><creator>Kono, Toshibumi</creator><creator>Nishihara, Atsushi</creator><creator>Hasegawa, Masahiro</creator><creator>Kono, Toshihiko</creator><creator>Sudo, Akihiro</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160901</creationdate><title>The Relationship of BMD Increases Between the First 12 Months and the Latter 12 Months by Daily Teriparatide Treatment</title><author>Niimi, Rui ; Kono, Toshibumi ; Nishihara, Atsushi ; Hasegawa, Masahiro ; Kono, Toshihiko ; Sudo, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-94a3d40a9d1681b8d328779d8cf1cbd73aab22331c51b938b15b568cb650d58d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone density</topic><topic>Bone Density - drug effects</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Bone Density Conservation Agents - therapeutic use</topic><topic>Bone Remodeling - drug effects</topic><topic>Bones</topic><topic>Cell Biology</topic><topic>Clinical trials</topic><topic>Drug Administration Schedule</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fractures</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lumbar Vertebrae - drug effects</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Osteoporosis - diagnosis</topic><topic>Osteoporosis - drug therapy</topic><topic>Retrospective Studies</topic><topic>Teriparatide - administration & dosage</topic><topic>Teriparatide - therapeutic use</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niimi, Rui</creatorcontrib><creatorcontrib>Kono, Toshibumi</creatorcontrib><creatorcontrib>Nishihara, Atsushi</creatorcontrib><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Kono, Toshihiko</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niimi, Rui</au><au>Kono, Toshibumi</au><au>Nishihara, Atsushi</au><au>Hasegawa, Masahiro</au><au>Kono, Toshihiko</au><au>Sudo, Akihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship of BMD Increases Between the First 12 Months and the Latter 12 Months by Daily Teriparatide Treatment</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>99</volume><issue>3</issue><spage>282</spage><epage>288</epage><pages>282-288</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>The degree of correlation between the first 12 months and the latter 12 months of increased bone mineral density (BMD) with teriparatide treatment is unknown. We retrospectively investigated the correlation between the first 12 months and the latter 12 months of increased BMD owing to teriparatide treatment. We retrospectively analyzed 357 patients (mean age, 78 years) with osteoporosis treated with teriparatide 20 μg/day for 24 months. The primary efficacy measure was the correlation between lumbar spine (LS) and femoral neck (FN) BMD increases from baseline to 12 months and from 12 to 24 months. The correlation between the first 12 months and the latter 12 months of increased BMD was evaluated. We investigated the correlation between the increases in BMD and the baseline procollagen type I N-terminal propeptide (PINP) concentration. LS BMD significantly increased by 9.7 ± 8.3 % in the first 12 months and 3.5 ± 4.8 % in the latter 12 months. FN BMD increased by 2.2 ± 8.4 % in the first 12 months and 1.3 ± 4.9 % in the latter 12 months. Increased LS and FN BMD were not significantly correlated between the first 12 months and the latter 12 months. The serum baseline PINP concentration was correlated with the LS BMD in the first 12 months, and similarly, the PINP concentration at 12 months was correlated with the latter 12 months of increased LS BMD. Increased BMD by teriparatide treatment in the first 12 months and the latter 12 months was not significantly correlated.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27206528</pmid><doi>10.1007/s00223-016-0151-5</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biochemistry Biomedical and Life Sciences Bone density Bone Density - drug effects Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - therapeutic use Bone Remodeling - drug effects Bones Cell Biology Clinical trials Drug Administration Schedule Endocrinology Female Fractures Humans Life Sciences Lumbar Vertebrae - drug effects Lumbar Vertebrae - physiopathology Male Middle Aged Original Research Orthopedics Osteoporosis Osteoporosis - diagnosis Osteoporosis - drug therapy Retrospective Studies Teriparatide - administration & dosage Teriparatide - therapeutic use Time Factors Treatment Outcome |
| title | The Relationship of BMD Increases Between the First 12 Months and the Latter 12 Months by Daily Teriparatide Treatment |
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