The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes

Autophagosome formation in yeast entails starvation-induced assembly of the pre-autophagosomal structure (PAS), in which multiple Atg1 complexes (composed of Atg1, Atg13, and the Atg17-Atg29-Atg31 subcomplex) are initially engaged. However, the molecular mechanisms underlying the multimeric assembly...

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Veröffentlicht in:	Developmental cell 2016-07, Vol.38 (1), p.86-99
Hauptverfasser:	Yamamoto, Hayashi, Fujioka, Yuko, Suzuki, Sho W., Noshiro, Daisuke, Suzuki, Hironori, Kondo-Kakuta, Chika, Kimura, Yayoi, Hirano, Hisashi, Ando, Toshio, Noda, Nobuo N., Ohsumi, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Autophagy Autophagy-Related Proteins - chemistry Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Phagosomes - physiology Phosphorylation Protein Binding Protein Conformation Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Homology, Amino Acid
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