3, 3′-Neolignans from Pithecellobium clypearia Benth and their anti-inflammatory activity
The twigs and leaves of Pithecellobium clypearia Benth have been used as a folk medicine for the treatment of diseases related to inflammation in southern China for many years. To search for novel bioactive constituents as lead structures for anti-inflammatory drug development, seven new 3, 3′-neoli...
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| Veröffentlicht in: | Fitoterapia 2016-07, Vol.112, p.16-21 |
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| creator | Lou, Li-Li Li, Lin-Guang Liu, Qing-Bo Li, Dan-Qi Liu, Zhi-Xiang Huang, Xiao-Xiao Song, Shao-Jiang |
| description | The twigs and leaves of Pithecellobium clypearia Benth have been used as a folk medicine for the treatment of diseases related to inflammation in southern China for many years. To search for novel bioactive constituents as lead structures for anti-inflammatory drug development, seven new 3, 3′-neolignans (1–7), together with four known ones (8–11) were isolated from the 70% EtOH extract of the twigs and leaves of P. clypearia. Their structures were determined by spectroscopic analyses, especially the 1D, 2D NMR and CD spectra. The antioxidant and anti-inflammatory activities of all the isolated compounds were investigated. Among them, compound 11 showed promising activity against nitric oxide (NO) and considerable antioxidant activity. These findings will help in the effective use of P. clypearia as a valuable source of novel compounds for the prevention and treatment of inflammation-related disorders.
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| doi_str_mv | 10.1016/j.fitote.2016.04.021 |
| format | Article |
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[Display omitted]</description><subject>3, 3′-neolignans</subject><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Antioxidant</subject><subject>Fabaceae - chemistry</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - isolation & purification</subject><subject>Lignans - chemistry</subject><subject>Lignans - isolation & purification</subject><subject>Mice</subject><subject>Molecular Structure</subject><subject>Nitric Oxide - metabolism</subject><subject>Pithecellobium</subject><subject>Pithecellobium clypearia Benth</subject><subject>Plant Extracts - chemistry</subject><subject>RAW 264.7 Cells</subject><issn>0367-326X</issn><issn>1873-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAQgC1UVBboG6Aqxx5I8KwdO7kgFQRtJQQ9FAmJg-U44-JVEi-2F2lvPBOPxJPg1VKOPc2M9M3fR8gR0AooiJNFZV3yCat5rirKKzqHHTKDRrJStBI-kRllQpZsLu72yH6MC0qhZhw-k725BAaCwozcs-OCvT6_lNfoB_d30lMsbPBj8dulBzQ4DL5zq7Eww3qJOjhdnOGUHgo99UUGXMhZcqWb7KDHUScf1oU2yT25tD4ku1YPEb-8xwNye3nx5_xneXXz49f596vSsLZOJQhA3ljTyRol57rtpdVS0Bat7qVGwdFIo7ngXS36jgHjbW8a29RcUCE0OyDftnOXwT-uMCY1urg5XU_oV1FBA9mKaCnLKN-iJvgYA1q1DG7UYa2Aqo1WtVBbrWqjVVGustbc9vV9w6obsf9o-ucxA6dbAPOfTw6DisbhZLB3AU1SvXf_3_AGt5eMqg</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Lou, Li-Li</creator><creator>Li, Lin-Guang</creator><creator>Liu, Qing-Bo</creator><creator>Li, Dan-Qi</creator><creator>Liu, Zhi-Xiang</creator><creator>Huang, Xiao-Xiao</creator><creator>Song, Shao-Jiang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-9074-2467</orcidid></search><sort><creationdate>201607</creationdate><title>3, 3′-Neolignans from Pithecellobium clypearia Benth and their anti-inflammatory activity</title><author>Lou, Li-Li ; 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To search for novel bioactive constituents as lead structures for anti-inflammatory drug development, seven new 3, 3′-neolignans (1–7), together with four known ones (8–11) were isolated from the 70% EtOH extract of the twigs and leaves of P. clypearia. Their structures were determined by spectroscopic analyses, especially the 1D, 2D NMR and CD spectra. The antioxidant and anti-inflammatory activities of all the isolated compounds were investigated. Among them, compound 11 showed promising activity against nitric oxide (NO) and considerable antioxidant activity. These findings will help in the effective use of P. clypearia as a valuable source of novel compounds for the prevention and treatment of inflammation-related disorders.
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| subjects | 3, 3′-neolignans Animals Anti-inflammatory Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Antioxidant Fabaceae - chemistry Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Lignans - chemistry Lignans - isolation & purification Mice Molecular Structure Nitric Oxide - metabolism Pithecellobium Pithecellobium clypearia Benth Plant Extracts - chemistry RAW 264.7 Cells |
| title | 3, 3′-Neolignans from Pithecellobium clypearia Benth and their anti-inflammatory activity |
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