BAFF overexpression increases lymphocytic infiltration in Sjögren's target tissue, but only inefficiently promotes ectopic B-cell differentiation

Abstract B-cell activating factor (BAFF) levels are increased in rheumatoid arthritis, lupus and primary Sjögren's syndrome (pSS). However, BAFF contribution to pathogenesis is not completely understood. In pSS, immune infiltration of the salivary and lacrimal glands leads to xerostomia and xer...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2016-08, Vol.169, p.69-79
Hauptverfasser:	Ding, Jian, Zhang, Wei, Haskett, Scott, Pellerin, Alex, Xu, Shanqin, Petersen, Britta, Jandreski, Luke, Hamann, Stefan, Reynolds, Taylor L, Zheng, Timothy S, Mingueneau, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Autoimmunity Autoimmunity - genetics Autoimmunity - immunology B cells B-Cell Activating Factor - genetics B-Cell Activating Factor - immunology B-Cell Activating Factor - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology BAFF Cell Differentiation - genetics Cell Differentiation - immunology Cells, Cultured Ectopic germinal center Flow Cytometry Gene Expression Profiling - methods Germinal Center - immunology Germinal Center - metabolism Immunohistochemistry Lacrimal Apparatus - immunology Lacrimal Apparatus - metabolism Male Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Oligonucleotide Array Sequence Analysis Sjogren's Syndrome - genetics Sjogren's Syndrome - immunology Sjogren's Syndrome - metabolism Sjögren's syndrome Xerophthalmia - genetics Xerophthalmia - immunology Xerophthalmia - metabolism Xerostomia - genetics Xerostomia - immunology Xerostomia - metabolism
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