The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey
Bifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of alle...
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| Veröffentlicht in: | Anaerobe 2014-08, Vol.28, p.98-103 |
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| creator | Akay, Hatice Kubra Bahar Tokman, Hrisi Hatipoglu, Nevin Hatipoglu, Huseyin Siraneci, Rengin Demirci, Mehmet Borsa, Baris Ata Yuksel, Pelin Karakullukcu, Asiye Kangaba, Achille Aime Sirekbasan, Serhat Aka, Sibel Mamal Torun, Muzeyyen Kocazeybek, Bekir S. |
| description | Bifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of allergic diseases. This study aimed to compare the faecal Bifidobacterium species of allergic children to those of healthy children to detect species level differences in faecal distribution. Stool samples were obtained from 99 children between 0 and 3 years of age whose clinical symptoms and laboratory reports were compatible with atopic dermatitis and allergic asthma. Samples were also obtained from 102 healthy children who were similar to the case group with respect to age and sex. Bifidobacteria were isolated by culture and identified at the genus level by API 20 A. In addition, 7 unique species-specific primers were used for the molecular characterization of bifidobacteria. The McNemar test was used for statistical analyses, and p |
| doi_str_mv | 10.1016/j.anaerobe.2014.05.006 |
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Statistical analysis revealed a significant difference in the prevalence of B. longum between these two groups (X2: 11.2, p < 0.001). However, no significant differences in the prevalence of other Bifidobacterium species were found between faecal samples from healthy and allergic children. (p > 0.05). The significant difference in the isolation of B. longum from our study groups suggests that this species favors the host by preventing the development of asthma and allergic dermatitis. Based on these results, we propose that the production of probiotics in accordance with country-specific Bifidobacterium species densities would improve public health. Thus, country-specific prospective case–control studies that collect broad data sets are needed.
•Bifidobacteria were isolated from fecal samples of healthy and allergic children.•The distribution of Bifidobacterium species in fecal samples were determined by PCR.•In 0–1 and 1–2 aged allergic children's samples Bifidobacteriumlongum was found significantly low.</description><identifier>ISSN: 1075-9964</identifier><identifier>EISSN: 1095-8274</identifier><identifier>DOI: 10.1016/j.anaerobe.2014.05.006</identifier><identifier>PMID: 24878320</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Allergic asthma ; Allergic dermatitis ; Asthma - epidemiology ; Asthma - prevention & control ; Bifidobacteria ; Bifidobacteriales Infections - microbiology ; Bifidobacterium - immunology ; Bifidobacterium - isolation & purification ; Bifidobacterium longum ; Case-Control Studies ; Child, Preschool ; Children ; Cross-Sectional Studies ; Dermatitis, Atopic - epidemiology ; Dermatitis, Atopic - prevention & control ; Feces - microbiology ; Female ; Humans ; Infant ; Male ; Prospective Studies ; Turkey ; Turkey - epidemiology</subject><ispartof>Anaerobe, 2014-08, Vol.28, p.98-103</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-593f9638383d954b841fc208e3781b9dd56d452bb587a662cd71f722c768acd63</citedby><cites>FETCH-LOGICAL-c401t-593f9638383d954b841fc208e3781b9dd56d452bb587a662cd71f722c768acd63</cites><orcidid>0000-0001-6240-7576 ; 0000-0002-7190-1522 ; 0000-0001-9670-2426 ; 0000-0001-7967-3539</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1075996414000560$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24878320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akay, Hatice Kubra</creatorcontrib><creatorcontrib>Bahar Tokman, Hrisi</creatorcontrib><creatorcontrib>Hatipoglu, Nevin</creatorcontrib><creatorcontrib>Hatipoglu, Huseyin</creatorcontrib><creatorcontrib>Siraneci, Rengin</creatorcontrib><creatorcontrib>Demirci, Mehmet</creatorcontrib><creatorcontrib>Borsa, Baris Ata</creatorcontrib><creatorcontrib>Yuksel, Pelin</creatorcontrib><creatorcontrib>Karakullukcu, Asiye</creatorcontrib><creatorcontrib>Kangaba, Achille Aime</creatorcontrib><creatorcontrib>Sirekbasan, Serhat</creatorcontrib><creatorcontrib>Aka, Sibel</creatorcontrib><creatorcontrib>Mamal Torun, Muzeyyen</creatorcontrib><creatorcontrib>Kocazeybek, Bekir S.</creatorcontrib><title>The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey</title><title>Anaerobe</title><addtitle>Anaerobe</addtitle><description>Bifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of allergic diseases. This study aimed to compare the faecal Bifidobacterium species of allergic children to those of healthy children to detect species level differences in faecal distribution. Stool samples were obtained from 99 children between 0 and 3 years of age whose clinical symptoms and laboratory reports were compatible with atopic dermatitis and allergic asthma. Samples were also obtained from 102 healthy children who were similar to the case group with respect to age and sex. Bifidobacteria were isolated by culture and identified at the genus level by API 20 A. In addition, 7 unique species-specific primers were used for the molecular characterization of bifidobacteria. The McNemar test was used for statistical analyses, and p < 0.05 was accepted as significant. Bifidobacterium longum was detected in 11 (11.1%) of the allergic children and in 31 (30.3%) of the healthy children.
Statistical analysis revealed a significant difference in the prevalence of B. longum between these two groups (X2: 11.2, p < 0.001). However, no significant differences in the prevalence of other Bifidobacterium species were found between faecal samples from healthy and allergic children. (p > 0.05). The significant difference in the isolation of B. longum from our study groups suggests that this species favors the host by preventing the development of asthma and allergic dermatitis. Based on these results, we propose that the production of probiotics in accordance with country-specific Bifidobacterium species densities would improve public health. Thus, country-specific prospective case–control studies that collect broad data sets are needed.
•Bifidobacteria were isolated from fecal samples of healthy and allergic children.•The distribution of Bifidobacterium species in fecal samples were determined by PCR.•In 0–1 and 1–2 aged allergic children's samples Bifidobacteriumlongum was found significantly low.</description><subject>Allergic asthma</subject><subject>Allergic dermatitis</subject><subject>Asthma - epidemiology</subject><subject>Asthma - prevention & control</subject><subject>Bifidobacteria</subject><subject>Bifidobacteriales Infections - microbiology</subject><subject>Bifidobacterium - immunology</subject><subject>Bifidobacterium - isolation & purification</subject><subject>Bifidobacterium longum</subject><subject>Case-Control Studies</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Turkey</subject><subject>Turkey - epidemiology</subject><issn>1075-9964</issn><issn>1095-8274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u3CAUha2qUZMmfYWIZTd2AAPGXTWK-idF6mayRvxcd5jaZgo40ez6ClXeME9SppM0y4gF6Oq791zOqapzghuCibjYNHrWEIOBhmLCGswbjMWr6oTgnteSduz1_t3xuu8FO67eprTBmBDG-ZvqmDLZyZbik-rPag0owqizD3Na-y0ykO8AZmT84F0w2maIXiM9O6THEeIPb5FOeT39q12E-Fx2EKcyKPv0AV2ibQxpCzb7W0ApL26HwoDww-_7Fu1Ax1SH0SG79qOLRc7PaLXEn7A7q44GPSZ493ifVjefP62uvtbX3798u7q8ri3DJNe8b4detLIc13NmJCODpVhC20lieue4cIxTY7jstBDUuo4MHaW2E1JbJ9rT6v1hbtnz1wIpq8knC-OoZwhLUkQSIrsiw15GOW-L70W9oOKA2vL7FGFQ2-gnHXeKYLVPTm3UU3Jqn5zCXJXkSuP5o8ZiJnD_256iKsDHAwDFlFsPUSXrYbbgfCwuKxf8Sxp_ASEgr1Q</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Akay, Hatice Kubra</creator><creator>Bahar Tokman, Hrisi</creator><creator>Hatipoglu, Nevin</creator><creator>Hatipoglu, Huseyin</creator><creator>Siraneci, Rengin</creator><creator>Demirci, Mehmet</creator><creator>Borsa, Baris Ata</creator><creator>Yuksel, Pelin</creator><creator>Karakullukcu, Asiye</creator><creator>Kangaba, Achille Aime</creator><creator>Sirekbasan, Serhat</creator><creator>Aka, Sibel</creator><creator>Mamal Torun, Muzeyyen</creator><creator>Kocazeybek, Bekir S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><orcidid>https://orcid.org/0000-0001-6240-7576</orcidid><orcidid>https://orcid.org/0000-0002-7190-1522</orcidid><orcidid>https://orcid.org/0000-0001-9670-2426</orcidid><orcidid>https://orcid.org/0000-0001-7967-3539</orcidid></search><sort><creationdate>20140801</creationdate><title>The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey</title><author>Akay, Hatice Kubra ; Bahar Tokman, Hrisi ; Hatipoglu, Nevin ; Hatipoglu, Huseyin ; Siraneci, Rengin ; Demirci, Mehmet ; Borsa, Baris Ata ; Yuksel, Pelin ; Karakullukcu, Asiye ; Kangaba, Achille Aime ; Sirekbasan, Serhat ; Aka, Sibel ; Mamal Torun, Muzeyyen ; Kocazeybek, Bekir S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-593f9638383d954b841fc208e3781b9dd56d452bb587a662cd71f722c768acd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergic asthma</topic><topic>Allergic dermatitis</topic><topic>Asthma - epidemiology</topic><topic>Asthma - prevention & control</topic><topic>Bifidobacteria</topic><topic>Bifidobacteriales Infections - microbiology</topic><topic>Bifidobacterium - immunology</topic><topic>Bifidobacterium - isolation & purification</topic><topic>Bifidobacterium longum</topic><topic>Case-Control Studies</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Dermatitis, Atopic - prevention & control</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Turkey</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akay, Hatice Kubra</creatorcontrib><creatorcontrib>Bahar Tokman, Hrisi</creatorcontrib><creatorcontrib>Hatipoglu, Nevin</creatorcontrib><creatorcontrib>Hatipoglu, Huseyin</creatorcontrib><creatorcontrib>Siraneci, Rengin</creatorcontrib><creatorcontrib>Demirci, Mehmet</creatorcontrib><creatorcontrib>Borsa, Baris Ata</creatorcontrib><creatorcontrib>Yuksel, Pelin</creatorcontrib><creatorcontrib>Karakullukcu, Asiye</creatorcontrib><creatorcontrib>Kangaba, Achille Aime</creatorcontrib><creatorcontrib>Sirekbasan, Serhat</creatorcontrib><creatorcontrib>Aka, Sibel</creatorcontrib><creatorcontrib>Mamal Torun, Muzeyyen</creatorcontrib><creatorcontrib>Kocazeybek, Bekir S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Anaerobe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akay, Hatice Kubra</au><au>Bahar Tokman, Hrisi</au><au>Hatipoglu, Nevin</au><au>Hatipoglu, Huseyin</au><au>Siraneci, Rengin</au><au>Demirci, Mehmet</au><au>Borsa, Baris Ata</au><au>Yuksel, Pelin</au><au>Karakullukcu, Asiye</au><au>Kangaba, Achille Aime</au><au>Sirekbasan, Serhat</au><au>Aka, Sibel</au><au>Mamal Torun, Muzeyyen</au><au>Kocazeybek, Bekir S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey</atitle><jtitle>Anaerobe</jtitle><addtitle>Anaerobe</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>28</volume><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>1075-9964</issn><eissn>1095-8274</eissn><abstract>Bifidobacteria are beneficial bacteria for humans. These bacteria are particularly effective at protecting against infectious diseases and modulating the immune response. It was shown that in newborns, the fecal distribution of the colonizing Bifidobacterium species influences the prevalence of allergic diseases. This study aimed to compare the faecal Bifidobacterium species of allergic children to those of healthy children to detect species level differences in faecal distribution. Stool samples were obtained from 99 children between 0 and 3 years of age whose clinical symptoms and laboratory reports were compatible with atopic dermatitis and allergic asthma. Samples were also obtained from 102 healthy children who were similar to the case group with respect to age and sex. Bifidobacteria were isolated by culture and identified at the genus level by API 20 A. In addition, 7 unique species-specific primers were used for the molecular characterization of bifidobacteria. The McNemar test was used for statistical analyses, and p < 0.05 was accepted as significant. Bifidobacterium longum was detected in 11 (11.1%) of the allergic children and in 31 (30.3%) of the healthy children.
Statistical analysis revealed a significant difference in the prevalence of B. longum between these two groups (X2: 11.2, p < 0.001). However, no significant differences in the prevalence of other Bifidobacterium species were found between faecal samples from healthy and allergic children. (p > 0.05). The significant difference in the isolation of B. longum from our study groups suggests that this species favors the host by preventing the development of asthma and allergic dermatitis. Based on these results, we propose that the production of probiotics in accordance with country-specific Bifidobacterium species densities would improve public health. Thus, country-specific prospective case–control studies that collect broad data sets are needed.
•Bifidobacteria were isolated from fecal samples of healthy and allergic children.•The distribution of Bifidobacterium species in fecal samples were determined by PCR.•In 0–1 and 1–2 aged allergic children's samples Bifidobacteriumlongum was found significantly low.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24878320</pmid><doi>10.1016/j.anaerobe.2014.05.006</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6240-7576</orcidid><orcidid>https://orcid.org/0000-0002-7190-1522</orcidid><orcidid>https://orcid.org/0000-0001-9670-2426</orcidid><orcidid>https://orcid.org/0000-0001-7967-3539</orcidid></addata></record> |
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| ispartof | Anaerobe, 2014-08, Vol.28, p.98-103 |
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| subjects | Allergic asthma Allergic dermatitis Asthma - epidemiology Asthma - prevention & control Bifidobacteria Bifidobacteriales Infections - microbiology Bifidobacterium - immunology Bifidobacterium - isolation & purification Bifidobacterium longum Case-Control Studies Child, Preschool Children Cross-Sectional Studies Dermatitis, Atopic - epidemiology Dermatitis, Atopic - prevention & control Feces - microbiology Female Humans Infant Male Prospective Studies Turkey Turkey - epidemiology |
| title | The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: A prospective study of 0–3 years-old children in Turkey |
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