Monoclonal antibodies targeting ST2L Domain 1 or Domain 3 differentially modulate IL-33-induced cytokine release by human mast cell and basophilic cell lines

•Monoclonal antibodies targeting Domain 1 or Domain3 of the IL-33 receptor ST2L differentially affect signaling complex formation.•The anti-ST2L antibodies differentially affect gene expression and cytokine release by mast cells as compared to basophils.•Blocking the first step in the formation of t...

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