Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis
The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between...
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| Veröffentlicht in: | Clinical rheumatology 2016-08, Vol.35 (8), p.2087-2092 |
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| creator | Macías-Hernández, Salvador Israel Miranda-Duarte, Antonio Ramírez-Mora, Isabel Cortés-González, Socorro Morones-Alba, Juan Daniel Olascoaga-Gómez, Andrea Coronado-Zarco, Roberto Soria-Bastida, María de los Angeles Nava-Bringas, Tania Inés Cruz-Medina, Eva |
| description | The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between 20 and 40 years of age, without diagnosis of knee OA. Their T2 relaxation time was measured through MRI, and their muscle strength (MS) was measured with an isokinetic dynamometer. Seventy-one participants were recruited, with an average age of 28.3 ± 5.5 years; 39 (55 %) were females. Negative correlations were found between T2RT and quadriceps peak torque (QPT) in males in the femur
r
= −0.46 (
p
= 0.01), tibia
r
= −0.49 (
p
= 0.02), and patella
r
= −0.44 (
p
= 0.01). In women, correlations were found among the femur
r
= −0.43 (
p
= 0.01), tibia
r
= −0.61 (
p
= 0.01), and patella
r
= −0.32 (
p
= 0.05) and among hamstring peak torque (HPT), in the femur
r
= −0.46 (
p
= 0.01), hamstring total work (HTW)
r
= −0.42 (
p
= 0.03), and tibia
r
= −0.33 (
p
= 0.04). Linear regression models showed good capacity to predict T2RT through QPT in both genders. The present study shows that early changes in femoral, tibial, and patellar cartilage are significantly correlated with MS, mainly QPT, and that these early changes might be explained by MS, which could play an important role in pre-clinical phases of the disease. |
| doi_str_mv | 10.1007/s10067-016-3333-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1811873361</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1811873361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-c4c3094f1ec7f5e2df897873112f52a72d1941aa5899f0e5e7e1a774dd2796d33</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxYMo9rX1A7iRgBs3o7nJzGSylFL_YMFNXYc0c_Oa50zyTDLUbv3kzfCeIoLQu7iXcH_nXMIh5CWwt8CYfJdr72XDoG9ErUY-IRtoRdso1aqnZMOkZI0ANZyQ05x3jDE-KHhOTrgUogXoNuTXl4BI5yXbCWkuCcO23FIbU8LJFMz0ztf3LvpQqDWp-MlskV5zuu5_muJjoMXPSH2g93EJW7pfKev3JpSjOvn8nTpjS0yZuphozAVjxW6TLz6fk2fOTBlfHOcZ-fbh8vriU3P19ePni_dXjW1ZV2q3gqnWAVrpOuSjG5QcpADgruNG8hFUC8Z0g1KOYYcSwUjZjiOXqh-FOCNvDr77FH8smIuefbY4TSZgXLKGAaD6iR4egTLJZcd4X9HX_6C7uKRQP1KpoediEGo1hANlU8w5odP75GeT7jUwvWapD1nqmqVes9Syal4dnZebGcc_it_hVYAfgFxXYYvpr9P_dX0AJH2qyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1886238391</pqid></control><display><type>article</type><title>Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Macías-Hernández, Salvador Israel ; Miranda-Duarte, Antonio ; Ramírez-Mora, Isabel ; Cortés-González, Socorro ; Morones-Alba, Juan Daniel ; Olascoaga-Gómez, Andrea ; Coronado-Zarco, Roberto ; Soria-Bastida, María de los Angeles ; Nava-Bringas, Tania Inés ; Cruz-Medina, Eva</creator><creatorcontrib>Macías-Hernández, Salvador Israel ; Miranda-Duarte, Antonio ; Ramírez-Mora, Isabel ; Cortés-González, Socorro ; Morones-Alba, Juan Daniel ; Olascoaga-Gómez, Andrea ; Coronado-Zarco, Roberto ; Soria-Bastida, María de los Angeles ; Nava-Bringas, Tania Inés ; Cruz-Medina, Eva</creatorcontrib><description>The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between 20 and 40 years of age, without diagnosis of knee OA. Their T2 relaxation time was measured through MRI, and their muscle strength (MS) was measured with an isokinetic dynamometer. Seventy-one participants were recruited, with an average age of 28.3 ± 5.5 years; 39 (55 %) were females. Negative correlations were found between T2RT and quadriceps peak torque (QPT) in males in the femur
r
= −0.46 (
p
= 0.01), tibia
r
= −0.49 (
p
= 0.02), and patella
r
= −0.44 (
p
= 0.01). In women, correlations were found among the femur
r
= −0.43 (
p
= 0.01), tibia
r
= −0.61 (
p
= 0.01), and patella
r
= −0.32 (
p
= 0.05) and among hamstring peak torque (HPT), in the femur
r
= −0.46 (
p
= 0.01), hamstring total work (HTW)
r
= −0.42 (
p
= 0.03), and tibia
r
= −0.33 (
p
= 0.04). Linear regression models showed good capacity to predict T2RT through QPT in both genders. The present study shows that early changes in femoral, tibial, and patellar cartilage are significantly correlated with MS, mainly QPT, and that these early changes might be explained by MS, which could play an important role in pre-clinical phases of the disease.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-016-3333-7</identifier><identifier>PMID: 27334115</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Cartilage, Articular - pathology ; Cross-Sectional Studies ; Female ; Femur - pathology ; Humans ; Knee Joint - pathology ; Linear Models ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Mexico ; Multivariate Analysis ; Muscle Strength ; Original Article ; Osteoarthritis, Knee - diagnostic imaging ; Patella - pathology ; Quadriceps Muscle - physiopathology ; Rheumatology ; Risk Factors ; Tibia - pathology ; Young Adult</subject><ispartof>Clinical rheumatology, 2016-08, Vol.35 (8), p.2087-2092</ispartof><rights>International League of Associations for Rheumatology (ILAR) 2016</rights><rights>Clinical Rheumatology is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c4c3094f1ec7f5e2df897873112f52a72d1941aa5899f0e5e7e1a774dd2796d33</citedby><cites>FETCH-LOGICAL-c405t-c4c3094f1ec7f5e2df897873112f52a72d1941aa5899f0e5e7e1a774dd2796d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-016-3333-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-016-3333-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27334115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macías-Hernández, Salvador Israel</creatorcontrib><creatorcontrib>Miranda-Duarte, Antonio</creatorcontrib><creatorcontrib>Ramírez-Mora, Isabel</creatorcontrib><creatorcontrib>Cortés-González, Socorro</creatorcontrib><creatorcontrib>Morones-Alba, Juan Daniel</creatorcontrib><creatorcontrib>Olascoaga-Gómez, Andrea</creatorcontrib><creatorcontrib>Coronado-Zarco, Roberto</creatorcontrib><creatorcontrib>Soria-Bastida, María de los Angeles</creatorcontrib><creatorcontrib>Nava-Bringas, Tania Inés</creatorcontrib><creatorcontrib>Cruz-Medina, Eva</creatorcontrib><title>Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between 20 and 40 years of age, without diagnosis of knee OA. Their T2 relaxation time was measured through MRI, and their muscle strength (MS) was measured with an isokinetic dynamometer. Seventy-one participants were recruited, with an average age of 28.3 ± 5.5 years; 39 (55 %) were females. Negative correlations were found between T2RT and quadriceps peak torque (QPT) in males in the femur
r
= −0.46 (
p
= 0.01), tibia
r
= −0.49 (
p
= 0.02), and patella
r
= −0.44 (
p
= 0.01). In women, correlations were found among the femur
r
= −0.43 (
p
= 0.01), tibia
r
= −0.61 (
p
= 0.01), and patella
r
= −0.32 (
p
= 0.05) and among hamstring peak torque (HPT), in the femur
r
= −0.46 (
p
= 0.01), hamstring total work (HTW)
r
= −0.42 (
p
= 0.03), and tibia
r
= −0.33 (
p
= 0.04). Linear regression models showed good capacity to predict T2RT through QPT in both genders. The present study shows that early changes in femoral, tibial, and patellar cartilage are significantly correlated with MS, mainly QPT, and that these early changes might be explained by MS, which could play an important role in pre-clinical phases of the disease.</description><subject>Adult</subject><subject>Cartilage, Articular - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Femur - pathology</subject><subject>Humans</subject><subject>Knee Joint - pathology</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mexico</subject><subject>Multivariate Analysis</subject><subject>Muscle Strength</subject><subject>Original Article</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Patella - pathology</subject><subject>Quadriceps Muscle - physiopathology</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Tibia - pathology</subject><subject>Young Adult</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU9rFTEUxYMo9rX1A7iRgBs3o7nJzGSylFL_YMFNXYc0c_Oa50zyTDLUbv3kzfCeIoLQu7iXcH_nXMIh5CWwt8CYfJdr72XDoG9ErUY-IRtoRdso1aqnZMOkZI0ANZyQ05x3jDE-KHhOTrgUogXoNuTXl4BI5yXbCWkuCcO23FIbU8LJFMz0ztf3LvpQqDWp-MlskV5zuu5_muJjoMXPSH2g93EJW7pfKev3JpSjOvn8nTpjS0yZuphozAVjxW6TLz6fk2fOTBlfHOcZ-fbh8vriU3P19ePni_dXjW1ZV2q3gqnWAVrpOuSjG5QcpADgruNG8hFUC8Z0g1KOYYcSwUjZjiOXqh-FOCNvDr77FH8smIuefbY4TSZgXLKGAaD6iR4egTLJZcd4X9HX_6C7uKRQP1KpoediEGo1hANlU8w5odP75GeT7jUwvWapD1nqmqVes9Syal4dnZebGcc_it_hVYAfgFxXYYvpr9P_dX0AJH2qyA</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Macías-Hernández, Salvador Israel</creator><creator>Miranda-Duarte, Antonio</creator><creator>Ramírez-Mora, Isabel</creator><creator>Cortés-González, Socorro</creator><creator>Morones-Alba, Juan Daniel</creator><creator>Olascoaga-Gómez, Andrea</creator><creator>Coronado-Zarco, Roberto</creator><creator>Soria-Bastida, María de los Angeles</creator><creator>Nava-Bringas, Tania Inés</creator><creator>Cruz-Medina, Eva</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis</title><author>Macías-Hernández, Salvador Israel ; Miranda-Duarte, Antonio ; Ramírez-Mora, Isabel ; Cortés-González, Socorro ; Morones-Alba, Juan Daniel ; Olascoaga-Gómez, Andrea ; Coronado-Zarco, Roberto ; Soria-Bastida, María de los Angeles ; Nava-Bringas, Tania Inés ; Cruz-Medina, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c4c3094f1ec7f5e2df897873112f52a72d1941aa5899f0e5e7e1a774dd2796d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Cartilage, Articular - pathology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Femur - pathology</topic><topic>Humans</topic><topic>Knee Joint - pathology</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mexico</topic><topic>Multivariate Analysis</topic><topic>Muscle Strength</topic><topic>Original Article</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Patella - pathology</topic><topic>Quadriceps Muscle - physiopathology</topic><topic>Rheumatology</topic><topic>Risk Factors</topic><topic>Tibia - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macías-Hernández, Salvador Israel</creatorcontrib><creatorcontrib>Miranda-Duarte, Antonio</creatorcontrib><creatorcontrib>Ramírez-Mora, Isabel</creatorcontrib><creatorcontrib>Cortés-González, Socorro</creatorcontrib><creatorcontrib>Morones-Alba, Juan Daniel</creatorcontrib><creatorcontrib>Olascoaga-Gómez, Andrea</creatorcontrib><creatorcontrib>Coronado-Zarco, Roberto</creatorcontrib><creatorcontrib>Soria-Bastida, María de los Angeles</creatorcontrib><creatorcontrib>Nava-Bringas, Tania Inés</creatorcontrib><creatorcontrib>Cruz-Medina, Eva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macías-Hernández, Salvador Israel</au><au>Miranda-Duarte, Antonio</au><au>Ramírez-Mora, Isabel</au><au>Cortés-González, Socorro</au><au>Morones-Alba, Juan Daniel</au><au>Olascoaga-Gómez, Andrea</au><au>Coronado-Zarco, Roberto</au><au>Soria-Bastida, María de los Angeles</au><au>Nava-Bringas, Tania Inés</au><au>Cruz-Medina, Eva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>35</volume><issue>8</issue><spage>2087</spage><epage>2092</epage><pages>2087-2092</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>The objective of this study is to correlate T2 relaxation time (T2RT), measured by magnetic resonance imaging (MRI) with quadriceps and hamstring strength in young participants with risk factors for knee osteoarthritis (OA). A descriptive cross-sectional study was conducted with participants between 20 and 40 years of age, without diagnosis of knee OA. Their T2 relaxation time was measured through MRI, and their muscle strength (MS) was measured with an isokinetic dynamometer. Seventy-one participants were recruited, with an average age of 28.3 ± 5.5 years; 39 (55 %) were females. Negative correlations were found between T2RT and quadriceps peak torque (QPT) in males in the femur
r
= −0.46 (
p
= 0.01), tibia
r
= −0.49 (
p
= 0.02), and patella
r
= −0.44 (
p
= 0.01). In women, correlations were found among the femur
r
= −0.43 (
p
= 0.01), tibia
r
= −0.61 (
p
= 0.01), and patella
r
= −0.32 (
p
= 0.05) and among hamstring peak torque (HPT), in the femur
r
= −0.46 (
p
= 0.01), hamstring total work (HTW)
r
= −0.42 (
p
= 0.03), and tibia
r
= −0.33 (
p
= 0.04). Linear regression models showed good capacity to predict T2RT through QPT in both genders. The present study shows that early changes in femoral, tibial, and patellar cartilage are significantly correlated with MS, mainly QPT, and that these early changes might be explained by MS, which could play an important role in pre-clinical phases of the disease.</abstract><cop>London</cop><pub>Springer London</pub><pmid>27334115</pmid><doi>10.1007/s10067-016-3333-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2016-08, Vol.35 (8), p.2087-2092 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1811873361 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Cartilage, Articular - pathology Cross-Sectional Studies Female Femur - pathology Humans Knee Joint - pathology Linear Models Magnetic Resonance Imaging Male Medicine Medicine & Public Health Mexico Multivariate Analysis Muscle Strength Original Article Osteoarthritis, Knee - diagnostic imaging Patella - pathology Quadriceps Muscle - physiopathology Rheumatology Risk Factors Tibia - pathology Young Adult |
| title | Knee muscle strength correlates with joint cartilage T2 relaxation time in young participants with risk factors for osteoarthritis |
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