Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature
Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an associatio...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2016-05, Vol.18 (5), p.444-453 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Mikkelsen, K. H. Allin, K. H. Knop, F. K. |
| description | Gut bacteria are involved in a number of host metabolic processes and have been implicated in the development of obesity and type 2 diabetes in humans. The use of antibiotics changes the composition of the gut microbiota and there is accumulating evidence from observational studies for an association between exposure to antibiotics and development of obesity and type 2 diabetes. In the present paper, we review human studies examining the effects of antibiotics on body weight regulation and glucose metabolism and discuss whether the observed findings may relate to alterations in the composition and function of the gut microbiota. |
| doi_str_mv | 10.1111/dom.12637 |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Antibiotics Appetite Regulation - drug effects Body weight Body Weight - drug effects Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - microbiology Dysbiosis - chemically induced Dysbiosis - microbiology Dysbiosis - physiopathology Energy Metabolism - drug effects Gastrointestinal Microbiome - drug effects Glucose metabolism Humans Insulin Resistance Intestinal microflora Literature reviews Metabolism Microbiota Models, Biological Obesity Observational Studies as Topic observational study Overweight - etiology Overweight - microbiology pharmaco-epidemiology type 2 diabetes |
| title | Effect of antibiotics on gut microbiota, glucose metabolism and body weight regulation: a review of the literature |
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