Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice
[Display omitted] •Maternal cadmium (Cd) exposure during pregnancy induces fetal growth restriction (FGR).•After maternal Cd exposure, only trace amounts of Cd could pass from dam to placentas and fetuses.•Maternal Cd exposure reduces placental zinc (Zn) transport through down-regulating the express...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2016-08, Vol.63, p.174-182 |
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| container_title | Reproductive toxicology (Elmsford, N.Y.) |
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| creator | Wang, Hua Wang, Ying Bo, Qing-Li Ji, Yan-Li Liu, Lu Hu, Yong-Fang Chen, Yuan-Hua Zhang, Jun Zhao, Ling-Li Xu, De-Xiang |
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•Maternal cadmium (Cd) exposure during pregnancy induces fetal growth restriction (FGR).•After maternal Cd exposure, only trace amounts of Cd could pass from dam to placentas and fetuses.•Maternal Cd exposure reduces placental zinc (Zn) transport through down-regulating the expression of Zn transporters in mice.
Cadmium (Cd) is linked with increased risk of fetal growth restriction (FGR). Nevertheless, the mechanism remains unknown. This study established a mouse model of Cd-induced FGR through two exposure methods. Pregnant mice were either administered with CdCl2 (5, 50 and 250ppm) throughout pregnancy through drinking water or intraperitoneally injected with CdCl2 (4.5mg/kg) on GD9. As expected, fetal weight and crown-rump length were reduced in a gender-independent manner. Interestingly, Mt1 and Mt2, two metallothionein genes, were up-regulated in maternal liver. Correspondingly, Cd accumulated mainly in maternal liver and kidney, and only trace amounts of Cd could pass from dam to placentas and fetuses. Further analysis showed that placental Zn concentration was elevated. Conversely, embryonic Zn concentration was reduced. Moreover, placental Znt1 and Znt2, two zinc transporters, were down-regulated in Cd-exposed mice. These results suggest that maternal Cd exposure during pregnancy reduces placental Zn transport and induces fetal growth restriction. |
| doi_str_mv | 10.1016/j.reprotox.2016.06.010 |
| format | Article |
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•Maternal cadmium (Cd) exposure during pregnancy induces fetal growth restriction (FGR).•After maternal Cd exposure, only trace amounts of Cd could pass from dam to placentas and fetuses.•Maternal Cd exposure reduces placental zinc (Zn) transport through down-regulating the expression of Zn transporters in mice.
Cadmium (Cd) is linked with increased risk of fetal growth restriction (FGR). Nevertheless, the mechanism remains unknown. This study established a mouse model of Cd-induced FGR through two exposure methods. Pregnant mice were either administered with CdCl2 (5, 50 and 250ppm) throughout pregnancy through drinking water or intraperitoneally injected with CdCl2 (4.5mg/kg) on GD9. As expected, fetal weight and crown-rump length were reduced in a gender-independent manner. Interestingly, Mt1 and Mt2, two metallothionein genes, were up-regulated in maternal liver. Correspondingly, Cd accumulated mainly in maternal liver and kidney, and only trace amounts of Cd could pass from dam to placentas and fetuses. Further analysis showed that placental Zn concentration was elevated. Conversely, embryonic Zn concentration was reduced. Moreover, placental Znt1 and Znt2, two zinc transporters, were down-regulated in Cd-exposed mice. These results suggest that maternal Cd exposure during pregnancy reduces placental Zn transport and induces fetal growth restriction.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2016.06.010</identifier><identifier>PMID: 27319394</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cadmium ; Cadmium - blood ; Cadmium - pharmacokinetics ; Cadmium - toxicity ; Cation Transport Proteins - genetics ; Down-Regulation ; Environmental Pollutants - blood ; Environmental Pollutants - pharmacokinetics ; Environmental Pollutants - toxicity ; Female ; Fetal Blood - chemistry ; Fetal growth restriction ; Fetal Growth Retardation - chemically induced ; Liver - metabolism ; Maternal-Fetal Exchange ; Metallothionein - genetics ; Mice ; Mouse ; Placenta ; Placenta - drug effects ; Placenta - metabolism ; Pregnancy ; Zinc ; Zinc - blood ; Zinc - metabolism</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2016-08, Vol.63, p.174-182</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d29bd881aefda862612bb4fce17430eed6861f2e95690ce21cf3df0e510d35ad3</citedby><cites>FETCH-LOGICAL-c368t-d29bd881aefda862612bb4fce17430eed6861f2e95690ce21cf3df0e510d35ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0890623816301496$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27319394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Bo, Qing-Li</creatorcontrib><creatorcontrib>Ji, Yan-Li</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Hu, Yong-Fang</creatorcontrib><creatorcontrib>Chen, Yuan-Hua</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Zhao, Ling-Li</creatorcontrib><creatorcontrib>Xu, De-Xiang</creatorcontrib><title>Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>[Display omitted]
•Maternal cadmium (Cd) exposure during pregnancy induces fetal growth restriction (FGR).•After maternal Cd exposure, only trace amounts of Cd could pass from dam to placentas and fetuses.•Maternal Cd exposure reduces placental zinc (Zn) transport through down-regulating the expression of Zn transporters in mice.
Cadmium (Cd) is linked with increased risk of fetal growth restriction (FGR). Nevertheless, the mechanism remains unknown. This study established a mouse model of Cd-induced FGR through two exposure methods. Pregnant mice were either administered with CdCl2 (5, 50 and 250ppm) throughout pregnancy through drinking water or intraperitoneally injected with CdCl2 (4.5mg/kg) on GD9. As expected, fetal weight and crown-rump length were reduced in a gender-independent manner. Interestingly, Mt1 and Mt2, two metallothionein genes, were up-regulated in maternal liver. Correspondingly, Cd accumulated mainly in maternal liver and kidney, and only trace amounts of Cd could pass from dam to placentas and fetuses. Further analysis showed that placental Zn concentration was elevated. Conversely, embryonic Zn concentration was reduced. Moreover, placental Znt1 and Znt2, two zinc transporters, were down-regulated in Cd-exposed mice. These results suggest that maternal Cd exposure during pregnancy reduces placental Zn transport and induces fetal growth restriction.</description><subject>Animals</subject><subject>Cadmium</subject><subject>Cadmium - blood</subject><subject>Cadmium - pharmacokinetics</subject><subject>Cadmium - toxicity</subject><subject>Cation Transport Proteins - genetics</subject><subject>Down-Regulation</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - pharmacokinetics</subject><subject>Environmental Pollutants - toxicity</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetal growth restriction</subject><subject>Fetal Growth Retardation - chemically induced</subject><subject>Liver - metabolism</subject><subject>Maternal-Fetal Exchange</subject><subject>Metallothionein - genetics</subject><subject>Mice</subject><subject>Mouse</subject><subject>Placenta</subject><subject>Placenta - drug effects</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Zinc</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJabZJ_0LwsRdvZyyvLN9SQr4goZfmLLTSONViS44kt0l_fbRs0mthQAw878zoYewMYY2A4ttuHWmOIYfndVP6NZRC-MBWKDteYwfyiK1A9lCLhstj9jmlHQC0Xd99YsdNx7Hnfbtij_c6U_R6rIy2k1umip7nkJZIVSS7GErVPGpDPhfkr_OmylH7NIeYK-1t5fwBGmgPPMbwJ_8qyZSjM9kFX4BqcoZO2cdBj4m-vL0n7OHq8ufFTX334_r24vtdbbiQubZNv7VSoqbBaikagc122w6GsGs5EFkhBQ4N9RvRg6EGzcDtALRBsHyjLT9hXw9zi5ynpdyhJpcMjaP2FJakUCLKlvedKKg4oCaGlCINao5u0vFFIai9ZLVT75LVXrKCUgglePa2Y9lOZP_F3q0W4PwAUPnpb0dRJePIG7IuksnKBve_Ha9Lc5ST</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Wang, Hua</creator><creator>Wang, Ying</creator><creator>Bo, Qing-Li</creator><creator>Ji, Yan-Li</creator><creator>Liu, Lu</creator><creator>Hu, Yong-Fang</creator><creator>Chen, Yuan-Hua</creator><creator>Zhang, Jun</creator><creator>Zhao, Ling-Li</creator><creator>Xu, De-Xiang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice</title><author>Wang, Hua ; Wang, Ying ; Bo, Qing-Li ; Ji, Yan-Li ; Liu, Lu ; Hu, Yong-Fang ; Chen, Yuan-Hua ; Zhang, Jun ; Zhao, Ling-Li ; Xu, De-Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d29bd881aefda862612bb4fce17430eed6861f2e95690ce21cf3df0e510d35ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cadmium</topic><topic>Cadmium - blood</topic><topic>Cadmium - pharmacokinetics</topic><topic>Cadmium - toxicity</topic><topic>Cation Transport Proteins - genetics</topic><topic>Down-Regulation</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - pharmacokinetics</topic><topic>Environmental Pollutants - toxicity</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetal growth restriction</topic><topic>Fetal Growth Retardation - chemically induced</topic><topic>Liver - metabolism</topic><topic>Maternal-Fetal Exchange</topic><topic>Metallothionein - genetics</topic><topic>Mice</topic><topic>Mouse</topic><topic>Placenta</topic><topic>Placenta - drug effects</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Zinc</topic><topic>Zinc - blood</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Bo, Qing-Li</creatorcontrib><creatorcontrib>Ji, Yan-Li</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Hu, Yong-Fang</creatorcontrib><creatorcontrib>Chen, Yuan-Hua</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Zhao, Ling-Li</creatorcontrib><creatorcontrib>Xu, De-Xiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hua</au><au>Wang, Ying</au><au>Bo, Qing-Li</au><au>Ji, Yan-Li</au><au>Liu, Lu</au><au>Hu, Yong-Fang</au><au>Chen, Yuan-Hua</au><au>Zhang, Jun</au><au>Zhao, Ling-Li</au><au>Xu, De-Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2016-08</date><risdate>2016</risdate><volume>63</volume><spage>174</spage><epage>182</epage><pages>174-182</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>[Display omitted]
•Maternal cadmium (Cd) exposure during pregnancy induces fetal growth restriction (FGR).•After maternal Cd exposure, only trace amounts of Cd could pass from dam to placentas and fetuses.•Maternal Cd exposure reduces placental zinc (Zn) transport through down-regulating the expression of Zn transporters in mice.
Cadmium (Cd) is linked with increased risk of fetal growth restriction (FGR). Nevertheless, the mechanism remains unknown. This study established a mouse model of Cd-induced FGR through two exposure methods. Pregnant mice were either administered with CdCl2 (5, 50 and 250ppm) throughout pregnancy through drinking water or intraperitoneally injected with CdCl2 (4.5mg/kg) on GD9. As expected, fetal weight and crown-rump length were reduced in a gender-independent manner. Interestingly, Mt1 and Mt2, two metallothionein genes, were up-regulated in maternal liver. Correspondingly, Cd accumulated mainly in maternal liver and kidney, and only trace amounts of Cd could pass from dam to placentas and fetuses. Further analysis showed that placental Zn concentration was elevated. Conversely, embryonic Zn concentration was reduced. Moreover, placental Znt1 and Znt2, two zinc transporters, were down-regulated in Cd-exposed mice. These results suggest that maternal Cd exposure during pregnancy reduces placental Zn transport and induces fetal growth restriction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27319394</pmid><doi>10.1016/j.reprotox.2016.06.010</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Cadmium Cadmium - blood Cadmium - pharmacokinetics Cadmium - toxicity Cation Transport Proteins - genetics Down-Regulation Environmental Pollutants - blood Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Female Fetal Blood - chemistry Fetal growth restriction Fetal Growth Retardation - chemically induced Liver - metabolism Maternal-Fetal Exchange Metallothionein - genetics Mice Mouse Placenta Placenta - drug effects Placenta - metabolism Pregnancy Zinc Zinc - blood Zinc - metabolism |
| title | Maternal cadmium exposure reduces placental zinc transport and induces fetal growth restriction in mice |
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