The Alternative Pathway of Complement and the Evolving Clinical-Pathophysiological Spectrum of Atypical Hemolytic Uremic Syndrome

Complement-mediated atypical hemolytic uremic syndrome (aHUS) comprises approximately 90% of cases of aHUS, and results from dysregulation of endothelial-anchored complement activation with resultant endothelial damage. The discovery of biomarker ADAMTS13 has enabled a more accurate diagnosis of thr...

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Veröffentlicht in:	The American journal of the medical sciences 2016-08, Vol.352 (2), p.177-190
1. Verfasser:	Berger, Bruce E., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative pathway Atypical hemolytic uremic syndrome Atypical Hemolytic Uremic Syndrome - immunology Atypical Hemolytic Uremic Syndrome - metabolism Atypical Hemolytic Uremic Syndrome - physiopathology Biomarkers Complement Complement Pathway, Alternative - physiology Complement storm Humans Immunity, Innate - physiology Internal Medicine
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