Complement inhibition in C3 glomerulopathy

Highlights • Dysregulation of the alternative pathway of complement plays a critical role in C3 glomerulopathy. • Ultra-rare variants in complement genes are identified in about 40% of C3 glomerulopathy patients. • C3 nephritic factors are present in the majority of patients with C3 glomerulopathy....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Seminars in immunology 2016-06, Vol.28 (3), p.241-249
Hauptverfasser:	Nester, Carla M, Smith, Richard J.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Biomarkers - metabolism C3 glomerulonephritis C3 glomerulopathy Complement Complement C3 - genetics Complement C3 - immunology Complement Inactivating Agents - therapeutic use Complement Pathway, Alternative Dense deposit disease Eculizumab Gene Frequency Genotype Glomerulonephritis, Membranous - genetics Glomerulonephritis, Membranous - immunology Glomerulonephritis, Membranous - therapy Humans Immunotherapy - methods Kidney - metabolism Kidney - pathology Membranoproliferative glomerulonephritis Polymorphism, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!