Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats

The flowers of Gentiana macrophylla have been usually applied to cure the joint inflammation and rheumatoid arthritis in Traditional Chinese Medicine. This work aimed to investigate the anti-rheumatoid arthritic effect and possible mechanism of iridoid glycosides from G. macrophylla (GMI) using an a...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-08, Vol.189, p.1-9
Hauptverfasser:	Jia, Na, Chu, Wei, Li, Yuwen, Ding, Likun, Duan, Jialin, Cui, Jia, Cao, Shanshan, Zhao, Chao, Wu, Yin, Wen, Aidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antirheumatic Agents - isolation & purification Antirheumatic Agents - pharmacology Arthritis, Experimental - blood Arthritis, Experimental - chemically induced Arthritis, Experimental - pathology Arthritis, Experimental - prevention & control Chromatography, High Pressure Liquid Collagen-induced arthritis Cyclooxygenase 2 - metabolism Cytokines - blood Flowers - chemistry Gentiana - chemistry Gentiana macrophylla Pall Gentiopicroside Inflammation Mediators - blood Iridoid Glucosides - isolation & purification Iridoid Glucosides - pharmacology Iridoid glycosides Iridoid Glycosides - isolation & purification Iridoid Glycosides - pharmacology Iridoids - isolation & purification Iridoids - pharmacology Joints - drug effects Joints - metabolism Joints - pathology Male Nitric Oxide Synthase Type II - metabolism Organ Size Phytotherapy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Rats, Sprague-Dawley Rheumatoid arthritis Spleen - drug effects Spleen - pathology Thymus Gland - drug effects Thymus Gland - pathology Time Factors
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