Characteristics of Schistosoma japonicum infection induced IFN‐γ and IL‐4 co‐expressing plasticity Th cells
Summary Schistosoma japonicum infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble facto...
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| Veröffentlicht in: | Immunology 2016-09, Vol.149 (1), p.25-34 |
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| creator | Chen, Dianhui Xie, Hongyan Cha, Hefei Qu, Jiale Wang, Mei Li, Lu Yu, Sifei Wu, Changyou Tang, Xiaoping Huang, Jun |
| description | Summary
Schistosoma japonicum infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble factors). In the present study, we found an accumulation of large numbers of IFN‐γ+ IL‐4+ CD4+ T cells in mouse livers. This IFN‐γ+ IL‐4+ cell population increased from 0·68 ± 0·57% in uninfected mice to 7·05 ± 3·0% by week 4 following infection and to 9·6 ± 5·28% by week 6, before decreasing to 6·3 ± 5·9% by week 8 in CD4 T cells. Moreover, IFN‐γ+ IL‐4+ Th cells were also found in mouse spleen and mesenteric lymph nodes 6 weeks after infection. The majority of the IFN‐γ+ IL‐4+ Th cells were thought to be related to a state of immune activation, and some were memory T cells. Moreover, we found that these S. japonicum infection‐induced IFN‐γ+ IL‐4+ cells could express interleukin‐2 (IL‐2), IL‐9, IL‐17 and high IL‐10 levels at 6 weeks after S. japonicum infection. Taken together, our data suggest the existence of a population of IFN‐γ+ IL‐4+ plasticity effector/memory Th cells following S. japonicum infection in C57BL/6 mice.
A population of IFN‐γ+IL‐4+ plasticity effector/memory Th cells exist in the liver of Schistosoma japonicum infected C57BL/6 mice, which could produce many kinds of cytokines. |
| doi_str_mv | 10.1111/imm.12623 |
| format | Article |
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Schistosoma japonicum infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble factors). In the present study, we found an accumulation of large numbers of IFN‐γ+ IL‐4+ CD4+ T cells in mouse livers. This IFN‐γ+ IL‐4+ cell population increased from 0·68 ± 0·57% in uninfected mice to 7·05 ± 3·0% by week 4 following infection and to 9·6 ± 5·28% by week 6, before decreasing to 6·3 ± 5·9% by week 8 in CD4 T cells. Moreover, IFN‐γ+ IL‐4+ Th cells were also found in mouse spleen and mesenteric lymph nodes 6 weeks after infection. The majority of the IFN‐γ+ IL‐4+ Th cells were thought to be related to a state of immune activation, and some were memory T cells. Moreover, we found that these S. japonicum infection‐induced IFN‐γ+ IL‐4+ cells could express interleukin‐2 (IL‐2), IL‐9, IL‐17 and high IL‐10 levels at 6 weeks after S. japonicum infection. Taken together, our data suggest the existence of a population of IFN‐γ+ IL‐4+ plasticity effector/memory Th cells following S. japonicum infection in C57BL/6 mice.
A population of IFN‐γ+IL‐4+ plasticity effector/memory Th cells exist in the liver of Schistosoma japonicum infected C57BL/6 mice, which could produce many kinds of cytokines.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1111/imm.12623</identifier><identifier>PMID: 27242265</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; CD4 T cells ; Cell Differentiation ; Cells, Cultured ; cytokines ; Female ; Immunologic Memory ; Interferon-gamma - metabolism ; interferon‐γ ; Interleukin-4 - metabolism ; interleukin‐4 ; liver ; Liver - immunology ; Liver - parasitology ; Mice ; Mice, Inbred C57BL ; Schistosoma japonicum ; Schistosoma japonicum - immunology ; Schistosomiasis japonica - immunology ; T-Lymphocyte Subsets - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; Th1-Th2 Balance</subject><ispartof>Immunology, 2016-09, Vol.149 (1), p.25-34</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3603-2776584d926799c0ce11e1647aba1ded0c734e700bbdeadb7ab6bf2142ef18813</citedby><cites>FETCH-LOGICAL-c3603-2776584d926799c0ce11e1647aba1ded0c734e700bbdeadb7ab6bf2142ef18813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimm.12623$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimm.12623$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27242265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Dianhui</creatorcontrib><creatorcontrib>Xie, Hongyan</creatorcontrib><creatorcontrib>Cha, Hefei</creatorcontrib><creatorcontrib>Qu, Jiale</creatorcontrib><creatorcontrib>Wang, Mei</creatorcontrib><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Yu, Sifei</creatorcontrib><creatorcontrib>Wu, Changyou</creatorcontrib><creatorcontrib>Tang, Xiaoping</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><title>Characteristics of Schistosoma japonicum infection induced IFN‐γ and IL‐4 co‐expressing plasticity Th cells</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
Schistosoma japonicum infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble factors). In the present study, we found an accumulation of large numbers of IFN‐γ+ IL‐4+ CD4+ T cells in mouse livers. This IFN‐γ+ IL‐4+ cell population increased from 0·68 ± 0·57% in uninfected mice to 7·05 ± 3·0% by week 4 following infection and to 9·6 ± 5·28% by week 6, before decreasing to 6·3 ± 5·9% by week 8 in CD4 T cells. Moreover, IFN‐γ+ IL‐4+ Th cells were also found in mouse spleen and mesenteric lymph nodes 6 weeks after infection. The majority of the IFN‐γ+ IL‐4+ Th cells were thought to be related to a state of immune activation, and some were memory T cells. Moreover, we found that these S. japonicum infection‐induced IFN‐γ+ IL‐4+ cells could express interleukin‐2 (IL‐2), IL‐9, IL‐17 and high IL‐10 levels at 6 weeks after S. japonicum infection. Taken together, our data suggest the existence of a population of IFN‐γ+ IL‐4+ plasticity effector/memory Th cells following S. japonicum infection in C57BL/6 mice.
A population of IFN‐γ+IL‐4+ plasticity effector/memory Th cells exist in the liver of Schistosoma japonicum infected C57BL/6 mice, which could produce many kinds of cytokines.</description><subject>Animals</subject><subject>CD4 T cells</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>cytokines</subject><subject>Female</subject><subject>Immunologic Memory</subject><subject>Interferon-gamma - metabolism</subject><subject>interferon‐γ</subject><subject>Interleukin-4 - metabolism</subject><subject>interleukin‐4</subject><subject>liver</subject><subject>Liver - immunology</subject><subject>Liver - parasitology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Schistosoma japonicum</subject><subject>Schistosoma japonicum - immunology</subject><subject>Schistosomiasis japonica - immunology</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Th1-Th2 Balance</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFOwzAUhi0EoqUwcAHkEYa0tpM4yYgqCpVaGChz5Dgv1FUSBzsRdOMI3IV7cAhOgkuADS_v_danT08_QqeUjKl7E1VVY8o48_fQkPo89FjIo300JIQmHotJOEBH1m5c9EkYHqIBi1jAGA-HyEzXwgjZglG2VdJiXeB7uXZBW10JvBGNrpXsKqzqAmSrdO22vJOQ4_ns9vP17eMdi9qFhdsDLLUb8NIYsFbVj7gpxc6r2i1erbGEsrTH6KAQpYWTnzlCD7Or1fTGW9xdz6eXC0_6nPgeiyIexkGeMB4liSQSKAXKg0hkguaQExn5AUSEZFkOIs_cP88KRgMGBY1j6o_Qee9tjH7qwLZppezuAlGD7mxKY0pZEvsxd-hFj0qjrTVQpI1RlTDblJJ0V3HqKk6_K3bs2Y-2yyrI_8jfTh0w6YFnVcL2f1M6Xy575ReinYoG</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Chen, Dianhui</creator><creator>Xie, Hongyan</creator><creator>Cha, Hefei</creator><creator>Qu, Jiale</creator><creator>Wang, Mei</creator><creator>Li, Lu</creator><creator>Yu, Sifei</creator><creator>Wu, Changyou</creator><creator>Tang, Xiaoping</creator><creator>Huang, Jun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Characteristics of Schistosoma japonicum infection induced IFN‐γ and IL‐4 co‐expressing plasticity Th cells</title><author>Chen, Dianhui ; Xie, Hongyan ; Cha, Hefei ; Qu, Jiale ; Wang, Mei ; Li, Lu ; Yu, Sifei ; Wu, Changyou ; Tang, Xiaoping ; Huang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3603-2776584d926799c0ce11e1647aba1ded0c734e700bbdeadb7ab6bf2142ef18813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>CD4 T cells</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>cytokines</topic><topic>Female</topic><topic>Immunologic Memory</topic><topic>Interferon-gamma - metabolism</topic><topic>interferon‐γ</topic><topic>Interleukin-4 - metabolism</topic><topic>interleukin‐4</topic><topic>liver</topic><topic>Liver - immunology</topic><topic>Liver - parasitology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Schistosoma japonicum</topic><topic>Schistosoma japonicum - immunology</topic><topic>Schistosomiasis japonica - immunology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><topic>Th1-Th2 Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Dianhui</creatorcontrib><creatorcontrib>Xie, Hongyan</creatorcontrib><creatorcontrib>Cha, Hefei</creatorcontrib><creatorcontrib>Qu, Jiale</creatorcontrib><creatorcontrib>Wang, Mei</creatorcontrib><creatorcontrib>Li, Lu</creatorcontrib><creatorcontrib>Yu, Sifei</creatorcontrib><creatorcontrib>Wu, Changyou</creatorcontrib><creatorcontrib>Tang, Xiaoping</creatorcontrib><creatorcontrib>Huang, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Dianhui</au><au>Xie, Hongyan</au><au>Cha, Hefei</au><au>Qu, Jiale</au><au>Wang, Mei</au><au>Li, Lu</au><au>Yu, Sifei</au><au>Wu, Changyou</au><au>Tang, Xiaoping</au><au>Huang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of Schistosoma japonicum infection induced IFN‐γ and IL‐4 co‐expressing plasticity Th cells</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2016-09</date><risdate>2016</risdate><volume>149</volume><issue>1</issue><spage>25</spage><epage>34</epage><pages>25-34</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
Schistosoma japonicum infection can induce granulomatous inflammation and cause tissue damage in the mouse liver. The cytokine secretion profile of T helper (Th) cells depends on both the nature of the activating stimulus and the local microenvironment (e.g. cytokines and other soluble factors). In the present study, we found an accumulation of large numbers of IFN‐γ+ IL‐4+ CD4+ T cells in mouse livers. This IFN‐γ+ IL‐4+ cell population increased from 0·68 ± 0·57% in uninfected mice to 7·05 ± 3·0% by week 4 following infection and to 9·6 ± 5·28% by week 6, before decreasing to 6·3 ± 5·9% by week 8 in CD4 T cells. Moreover, IFN‐γ+ IL‐4+ Th cells were also found in mouse spleen and mesenteric lymph nodes 6 weeks after infection. The majority of the IFN‐γ+ IL‐4+ Th cells were thought to be related to a state of immune activation, and some were memory T cells. Moreover, we found that these S. japonicum infection‐induced IFN‐γ+ IL‐4+ cells could express interleukin‐2 (IL‐2), IL‐9, IL‐17 and high IL‐10 levels at 6 weeks after S. japonicum infection. Taken together, our data suggest the existence of a population of IFN‐γ+ IL‐4+ plasticity effector/memory Th cells following S. japonicum infection in C57BL/6 mice.
A population of IFN‐γ+IL‐4+ plasticity effector/memory Th cells exist in the liver of Schistosoma japonicum infected C57BL/6 mice, which could produce many kinds of cytokines.</abstract><cop>England</cop><pmid>27242265</pmid><doi>10.1111/imm.12623</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals CD4 T cells Cell Differentiation Cells, Cultured cytokines Female Immunologic Memory Interferon-gamma - metabolism interferon‐γ Interleukin-4 - metabolism interleukin‐4 liver Liver - immunology Liver - parasitology Mice Mice, Inbred C57BL Schistosoma japonicum Schistosoma japonicum - immunology Schistosomiasis japonica - immunology T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology Th1-Th2 Balance |
| title | Characteristics of Schistosoma japonicum infection induced IFN‐γ and IL‐4 co‐expressing plasticity Th cells |
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