Herpesvirus saimiri Replaces ZAP-70 for CD3- and CD2-mediated T Cell Activation

The protein tyrosine kinase ZAP-70 plays a pivotal role involved in signal transduction through the T cell receptor and CD2. Defects in ZAP-70 result in severe combined immunodeficiency. We report that Herpesvirus saimiri, which does not code for a ZAP-70 homologue, can replace this tyrosine kinase....

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Veröffentlicht in:	The Journal of biological chemistry 2001-10, Vol.276 (40), p.36902-36908
Hauptverfasser:	Meinl, Edgar, Derfuss, Tobias, Pirzer, Rainer, Blank, Norbert, Lengenfelder, Doris, Blancher, Antoine, Le Deist, Françoise, Fleckenstein, Bernhard, Hivroz, Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Autocrine Communication CD2 antigen CD2 Antigens - physiology CD3 antigen CD3 Complex - physiology Cell Division Cell Transformation, Viral - physiology Cells, Cultured Enzyme Precursors - metabolism Flow Cytometry Herpesvirus 2, Saimiriine - physiology Herpesvirus saimiri Humans Intracellular Signaling Peptides and Proteins Lymphocyte Activation - physiology Membrane Proteins - metabolism Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - metabolism Receptors, Antigen, T-Cell - metabolism Syk Kinase Syk protein T-Lymphocytes - cytology T-Lymphocytes - physiology T-Lymphocytes - virology ZAP-70 protein ZAP-70 Protein-Tyrosine Kinase
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